Korean J Hematol.  2005 Sep;40(3):192-196. 10.5045/kjh.2005.40.3.192.

A Case of Extranodal NK/T Cell Lymphoma, Nasal Type Involving Anus

• Kim SY
• Kim YJ
• Kwon DA
• Lee SH
• Kim DW
• Im SA
• Kim TY
• Heo DS
• Bang YJ

• KMID: 1610815
• DOI: http://doi.org/10.5045/kjh.2005.40.3.192

Abstract

Involvement of the anus by a malignant lymphoma is rare, but occurs with a high incidence in acquired immunodeficiency syndrome patients, with most cases having a B-cell phenotype. Although NK/T cell lymphomas; the nasal type, often present with skin or gastrointestinal tract involvement, there has been no reported cases of anal involvement in Korea. Herein, we describe the case of a 23-year-old man who presented with fever, weight loss and a perianal abscess. A biopsy specimen of the anus revealed an extranodal NK/T cell lymphoma of the nasal type. In-situ hybridization for the Epstein-Barr Virus proved positive. Despite the use of combination chemotherapy, the patient died due to the disease 2 months after diagnosis. In patients presenting with a perianal lesion, other involved sites, as well as B symptoms, lymphoma involvement of the anus should be considered, with a biopsy of the anus performed.

Keyword

Lymphoma; Non-Hodgkin; Anus; Epstein-Barr virus

MeSH Terms

Abscess
Acquired Immunodeficiency Syndrome
Anal Canal*
B-Lymphocytes
Biopsy
Diagnosis
Drug Therapy, Combination
Fever
Gastrointestinal Tract
Herpesvirus 4, Human
Humans
Incidence
Korea
Lymphoma*
Phenotype
Skin
Weight Loss
Young Adult

Figure

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  Fig. 1. (A) Ulcerative lesion with exudate in the mouth floor. (B) Perianal erosions with discharge.

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  Fig. 2. The anal biopsy shows hypercellular lymphoid infiltration replacing normal subcutaneous structure with angiocentric and angiodestructive pattern (H&E stain, × 400).

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  Fig. 3. Immunohistochemial staining shows (A) CD3+ (× 400), (B) C D56+ (× 400), and (C) EBV+ (× 400).

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