J Korean Soc Pediatr Nephrol.  2006 Apr;10(1):65-71.

A Case of Idiopathic Renal Hypouricemia with URAT1 Gene Mutation who Showed Persistent Orange-colored Urine

Affiliations
  • 1Department of Pediatrics, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, Korea. yspark@amc.seoul.kr
  • 2Department of Pediatrics, Chungnam National University Hospital, Daejeon, Korea.
  • 3Department of Pediatrics, Ulsan University Hospital, Ulsan, Korea.

Abstract

Idiopathic renal hypouricemia is a disorder characterized by impaired urate handling in the renal tubules. Most patients with hypouricemia are asymptomatic and are found incidentally, but the condition is known to be at high risk for exercise-induced acute renal failure or urolithiasis. URAT1 protein encoded by SLC22A12 gene has been identified recently as a urate/anion exchanger in the human kidney. Inactivation mutations in SLC22A12 gene have been shown to cause renal idiopathic hypouricemia. We experienced a 3-year-old boy who presented with persistent orange-colored urine since infancy. His urine contained many uric acid crystals, while the serum showed hypouricemia(0.7 mg/dL). The fractional excretion of uric acid was increased to 41.7%. SLC22a12 gene analysis revealed W258X homozygote alleles. Renal hypouricemia must be included in the differential diagnosis of red-urine and SLC22A12 gene analysis is recommended in idiopathic renal hypouricemia.

Keyword

Hypouricemia; URAT1; SLC22A12; Orange-colored urine

MeSH Terms

Acute Kidney Injury
Alleles
Child, Preschool
Diagnosis, Differential
Homozygote
Humans
Kidney
Male
Uric Acid
Urolithiasis
Uric Acid
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