J Korean Assoc Oral Maxillofac Surg.
2005 Dec;31(6):492-495.
A study of the effect of cultured bone marrow stromal cells on peripheral nerve regeneration
- Affiliations
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- 1Department of Oral and Maxillofacial Surgery, College of Dentistry, Yonsei University, Seoul, South Korea. choibh@wonju.yonsei.ac.kr
- 2Department of Dentistry, Gangneung Asan Hospital, University of Ulsan, Gangneung, South Korea.
- 3Department of Periodontology, Ewha Womans University, Seoul, South Korea.
Abstract
- The role of cultured bone marrow stromal cells (BMSCs) in peripheral nerve regeneration was examined using an established rabbit peroneal nerve regeneration model. A 15-mm peroneal nerve defect was bridged with a vein filled with BMSCs (1 x 10(6)), which had been embedded in collagen gel. On the contralateral side, the defect was bridged with a vein filled with collagen gel alone. When the regenerated tissue was examined 4, 8 and 12 weeks after grafting, the number and diameter of the myelinated fibers in the side with the BMSCs were significantly higher than in the control side without the BMSCs. This demonstrates the potential of using cultured BMSCs in peripheral nerve regeneration.
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