J Korean Soc Pediatr Endocrinol.  2004 Dec;9(2):213-219.

Pachydermoperiostosis in a 19 Year-old Boy Presenting as an Acromegaly-like Syndrome

• Lim JS
• Lee JA
• Kim DH
• Lim KJ
• Jeun DG

Abstract

A nineteen year-old boy with progressive enlargement of the joints and distal extremities, clubbing, coarse facial features and hyperhidrosis was investigated. In physical examination, thickening of the scalp with furrowing (cutis verticis gyrata) and greasy thickening of skin (pachyderma) was prominent. His endocrine profile was normal. Radiological studies demonstrated bilateral symmetrical periosteal new bone formation with acroosteolysis and incidental microadenoma of pituitay gland. After extensive investigation to exclude systemic and endocrine causes, the patient was diagnosed as pachydermoperiostosis (PDP). PDP is a rare syndrome manifested clinically by finger clubbing, extremity enlargement, hypertrophic skin changes, and periosteal bone formation. The pathogenesis of the disorder has not been clarified though few endocrine abnormalities were seen. To aware of these clinical phenotype would help to differentiate PDP from acromegaly.

Keyword

Pachydermoperiostosis; Acromegaly; Cutis verticis gyrata

MeSH Terms

Acro-Osteolysis
Acromegaly
Extremities
Fingers
Humans
Hyperhidrosis
Joints
Male*
Osteoarthropathy, Primary Hypertrophic*
Osteogenesis
Phenotype
Physical Examination
Scalp
Skin
Young Adult*