Korean J Immunol.  1997 Mar;19(1):157-169.

Effect of BCG Immunotherapy on the Cytokine Production and Antitumor Activity against MBT - 2 Mouse Bladder Tumor

Abstract

Antitumor effects of Bacillus Calmette-Guerin (BCG) against superficial urinary bladder cancer is known to be strong when BCG is directly infused into the bladder, but its immunological mechanisms are poorly understood. These experiments were performed to elucidate the effects of intralesional or systemic administration of BCG on the antitumor activity in murine transitional cell carcinoma (MBT-2) model and on the production of cytokines by the activated splenocytes or macrophages. ...continue...


MeSH Terms

Animals
Bacillus
Carcinoma, Transitional Cell
Cytokines
Immunotherapy*
Macrophages
Mice*
Mycobacterium bovis*
Urinary Bladder Neoplasms*
Urinary Bladder*
Cytokines
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