J Genet Med.  1999 Dec;3(1):25-28.

Six-years' Experience of Pseudomosaicism and Maternal Cell Contamination in Cultured Amniocytes

Affiliations
  • 1Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea.
  • 2Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University, Seoul, Korea.
  • 3Department of Obstetrics and Gynecology, Seoul National University Hospital, 28 Yungun-dong, Chongno-Ku, Seoul, Korea.

Abstract

PURPOSE
: To present our experiences in pseudomosaicism or maternal celi contamination in genetic mid-trimester amniocentesis confirmed through percuraneous umbilical blood sampling.
METHODS
: From 1992 to 1997, repeated cytogenetic evaluation with fetal cord blood was carried out in 14 cases showing mosaic patterns.
RESULTS
: We confirmed pseudomosaicsm in 12 cases (85.7%) by repeated cytohenetic evaluation, and also maternal cell contamination in 2 cases.
CONCLUSIONS
: Repeated cytohenetic evaluation via percutaneous umbilical blood sampling was a rapid and useful method fof the confirmation of mosaicism resulted from genetic mid-trimester amnicentesis.

Keyword

Pseudomosaicism; Maternal cell contamination; Percutaneous umbilical blood sampling; Genetic amniocentesis
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