Korean J Hematol.
1999 Nov;34(4):568-572.
Nuclear Hyperploidy of Megakaryocytes and Platelet Aggregation Test in Essential Thrombocythemia
- Affiliations
-
- 1Department of Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
- 2Department of Clinical Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Abstract
- BACKGROUND
Essential thrombocythemia (ET) is a rare chronic myeloproliferative disorder characterized by an extremely high platelet count in the circulating blood and abnormal proliferation of the megakaryocytes in bone marrow, resulting in splenomegaly, thromboembolic or hemorrhagic complications. We studied the presence of nuclear hyperploidy of the megakaryocytes in bone marrow, the presence of abnormal response to the individual reagent on platelet aggregation test, and its clinical implication.
METHODS
We analyzed the 43 cases of ET at the Asan Medical Center between January, 1989 and March, 1999. The Polycythemia Vera Study Group criteria were used to diagnose ET.
RESULTS
Nuclear hyperploidy was observed at 43 cases (100%). Platelet aggregation test was done at 32 (74.4%) cases, of which 27 (84.4%) cases showed abnormal response to more than one reagent, 16 (50%) cases to more than two reagents. Abnormal response to epinephrine and collagen was most common, but 5 cases showed normal response. By individual reagent, 1 (3%) cases to adenosine diphosphate, 1 (3%) case to ristocetin, 22 (69%) cases to epinephrine, 19 (59%) cases to collagen showed abnormal response.
CONCLUSION
We observe that nuclear hyperploidy of the megakaryocyts and abnormal response on platelet aggregation test are frequent in ET in this study.
MeSH Terms
-
Adenosine Diphosphate
Blood Platelets*
Bone Marrow
Chungcheongnam-do
Collagen
Epinephrine
Indicators and Reagents
Megakaryocytes*
Myeloproliferative Disorders
Platelet Aggregation*
Platelet Count
Polycythemia Vera
Ristocetin
Splenomegaly
Thrombocythemia, Essential*
Adenosine Diphosphate
Collagen
Epinephrine
Indicators and Reagents
Ristocetin
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