Korean J Blood Transfus.  2007 Aug;18(2):116-120.

No Hemolytic Transfusion Reactions in a Patient with the Apparent Anti-e Autoantibody Following Transfusion of Packed Red Cells with CcDEe Phenotype

Affiliations
  • 1Department of Laboratory Medicine, Chonnam National University Medical School, Korea. hasomii@hanmail.net
  • 2Gwangju Shinga Hospital, Korea.
  • 3Gwangju-Jeonnam Red Cross Blood Center, Gwangju, Korea.

Abstract

Patients with alloantibody should be transfused with specific antigen negative blood, and in the case of autoantibody, the least incompatible blood on crossmatching can be transfused. Yet any transfusion cases that possessed autoantibody with the apparent antigen specificity have been rarely reported. A 62 year-old-woman with chronic renal failure underwent tests showing that the direct antiglobulin test was positive (2+) for IgG, the autocontrol test was positive, and the Rh phenotype of her erythrocytes was typed as group CcDEe. One unit of the e-positive packed red cells (PRCs) was transfused before an antibody identification test identified this antibody as autoantibody with an apparent e antigen specificity, but the level of hemoglobin increased from 6.3 g/dL to 7.4 g/dL without a hemolytic reaction or other transfusion side-effects.

Keyword

Autoimmune hemolytic anemia; Autoanti-e; Rh mimicking antibody
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