J Korean Assoc Maxillofac Plast Reconstr Surg.  2008 Mar;30(2):158-164.

Effect of platelet-rich plasma on autogenous bone graft for bone formation in rabbit

• Jeon MS
• Kim BG
• Song JH
• Yeon BM
• Lee YW
• Noh KL
• Kim DY
• Pang EO
• Kim JH
• Nam JH
• Gang TI
• Lim SC
• Park YJ

Abstract

PURPOSE : Recently, various materials were developed for enhancing bone formation capacity. Platelet rich plasma(PRP) is an autologous source with several growth factors and obtained by sequestering and concentrating platelets by gradient density centrifugation. This study was to evaluate the effect of PRP on healing of grafted bone.
MATERIALS AND METHODS
: Two blood samples were obtained and analysed for measuring platelet counts of normal blood and PRP. In experimental group, two defects of mandibular bone, 10mm in diameter and 4.0mm deep, were created in the mandible and immediately grafted with autogenous bone chips mixed with PRP. In control group, same bone defects were prepared and grafted with autogenous bone chips. Gelform was used for carrier of PRP. 2 weeks, 4 weeks, 8 weeks later, each group was evaluated with histologi-cal and histomorphometric analyses.
RESULTS
: According to histological observation, experimental group was showed more anastomosing newly-formed woven bone having osteoblastic activation than control group. According to histomorphometric analysis, there were 9.11% more newly-formed bone volume in experimental group than control group at 2 weeks, 7.91% more at 4 weeks, 20.08% more at 8 weeks.
CONCLUSION
: Our results demonstrated PRP in autogenous bone graft could enhance the bone formation.

Keyword

PRP; Autogenous bone

MeSH Terms

Blood Platelets
Centrifugation
Intercellular Signaling Peptides and Proteins
Mandible
Osteoblasts
Osteogenesis
Platelet Count
Platelet-Rich Plasma
Transplants
Intercellular Signaling Peptides and Proteins