J Korean Soc Radiol.  2009 Jul;61(1):1-8. 10.3348/jksr.2009.61.1.1.

The Corpus Callosum Area and Brain Volume in Alzheimer's Disease, Mild Cognitive Impairment and Healthy Controls

• Choi HS
• Seo HS
• Kim KK
• Yoon Y

• KMID: 1471212
• DOI: http://doi.org/10.3348/jksr.2009.61.1.1

Abstract

PURPOSE: To compare the corpus callosum (CC) area and brain volume among individuals with Alzheimer's disease (AD), mild cognitive impairment (MCI) and healthy controls (HC).
MATERIALS AND METHODS
To evaluate the relationship of CC area and brain volume in 111 subjects (M:F = 48:63; mean age, 56.9 years) without memory disturbance and 28 subjects (11:17; 66.7years) with memory disturbance. The 11 AD (3:8; 75.7 years), 17 MCI (8:9; 60.9 years) and 28 selected HC (11:17; 66.4 years) patients were investigated for comparison of their CC area and brain volume.
RESULTS
A good positive linear correlation was found between CC area and brain volume in subjects without and with memory disturbance (r = 0.64 and 0.66, respectively, p < 0.01). The CC area and brain volume in AD patients (498.7 +/- 72 mm2, 715.4 +/- 107 cm3) were significantly smaller than in MCI patients (595.9 +/- 108, 844.1 +/- 85) and the HCs (563.2 +/- 75, 818.9 +/- 109) (p < 0.05). The CC area and brain volume were not significantly different between MCI patients and the HCs.
CONCLUSION
The CC area was significantly correlated with brain volume. Both CC area and brain volume were significantly smaller in the AD patients

MeSH Terms

Alzheimer Disease
Brain
Cognition Disorders
Corpus Callosum
Humans
Memory
Mild Cognitive Impairment