J Korean Soc Pediatr Endocrinol.
2010 Aug;15(2):93-99.
The Clinical Characteristics of Type 2 Diabetes Mellitus with and without beta-cell Autoantibody in Children and Adolescents
- Affiliations
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- 1Department of Pediatrics, Yonsei University College of Medicine, Severance Children's Hospital, Seoul, Korea. dhkim3@yuhs.ac
Abstract
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PURPOSE: The aim of this study is to investigate the differences in clinical characteristics and disease process between autoantibody-positive and -negative patients with type 2 diabetes mellitus (DM).
METHODS
We investigated 162 patients diagnosed as DM between January 2000 and July 2009. 120 were classified as type 1 and 42 as type 2 DM. The clinical and laboratory data were obtained from medical records, retrospectively.
RESULTS
The age at diagnosis, average BMI and serum C-peptide levels were significantly higher in type 2 DM patients than in type 1 DM patients. Type 2 DM patients had a significantly higher family history of diabetes and less frequent ketonuria. There were no significant differences between autoantibody-positive and -negative type 2 DM patients in age at diagnosis, BMI, C-peptide levels, HbA1c levels or family history. During the follow-up period, C-peptide levels were lower in the autoantibody-positive group than in the autoantibody-negative group, while. HbA1c levels were higher in the autoantibody-positive group. However, these differences were not statistically significant.
CONCLUSION
In autoantibody-positive type 2 DM patients, progressive loss of beta-cell function leads to reduced insulin secretion and poor glycemic control as the disease progresses, and some may be reclassified as slowly progressive type 1 DM. Ccntinued and careful follow-up is therefore needed.
