J Korean Bone Joint Tumor Soc.  2010 Dec;16(2):51-54. 10.5292/jkbjts.2010.16.2.51.

Analysis of Local Recurrence of Giant Cell Tumor

• Cheon SH
• Park IH
• Cho HS
• Kim DH

• KMID: 1456317
• DOI: http://doi.org/10.5292/jkbjts.2010.16.2.51

Abstract

PURPOSE
This study was aimed to evaluate the recurrence rate of a giant cell tumor (GCT) of the bone.
MATERIALS AND METHODS
The medical records of fifty four patients who were diagnosed with a giant cell tumor of the bone between March 1980 and December 2008 were analysed retrospectively. Among 54 patients, 27 were men, remaining 27 were women with the mean age of 33.1 years (range, 13-67 years). The mean duration of follow-up was 67.1 months.
RESULTS
Twenty-one patients (38.9%) had a local recurrence. The mean time to recurrence was 21.5 months (range, 2-59 months). The local recurrence rate of the upper extremities was higher than that of lower extremities. According to Campanacci classification, patients with a grade I diseae had lower recurrence rate than those with grade II or III disease. There was no significant differences in the recurrence rates based on cryotherapy, the filling of bone cement or bone grafts and surgical margin.
CONCLUSION
To prevent local recurrence of GCT of bone, curettage of the tumor and elimination of the remaining cells are more important than adjuvant therapy.

Keyword

giant cell tumor of the bone; recurrence rate

MeSH Terms

Cryotherapy
Curettage
Female
Follow-Up Studies
Giant Cell Tumors
Giant Cells
Humans
Lower Extremity
Male
Medical Records
Recurrence
Retrospective Studies
Transplants
Upper Extremity

Reference

1. Campanacci M, Baldini S, Boriani S, Sudanese A. Giantcell tumor of bone. J Bone Joint Surg Am. 1987; 69:106–14.

2. Eckardt JJ, Grogan TJ. Giantcell tumor of bone. Clin Orthop. 1986; 204:45–58.

3. Siebenrock KA, Unni KK, Rock MG. Giantcell tumor of bone metastasizing to the lungs: a longterm followup. J Bone Joint Surg Br. 1998; 80:43–7.

4. Ghert MA, Rizzo M, Harrelson JM, Scully SP. Giantcell tumor of the appendicular skeleton. Clin Orthop. 2002; 400:201–10.

5. Goldenberg RR, Campbell CJ, Bonfiglio M. Giantcell tumor of bone. An analysis of two hundred and eighteen cases. J Bone Joint Surg Am. 1970; 52:619–64.

6. Larsson SE, Lorentzon R, Boquist L. Giantcell tumor of bone: A demographic, clinical, and histopathological study of all cases recorded in the Swedish Cancer Registry for the years 1958-1968. J Bone Joint Surg Am. 1975; 57:167–73.

7. Malawer MM, Bickels J, Meller I, Buch RG, Henshaw RW, Kol-lender Y. Cryosurgery in the treatment of giant cell tumor: a long term follow up study. Clin Orthop. 1999; 359:176–88.

8. O'Donnell RJ, Springfield DS, Motwani HK, Ready JE, Gebhardt MC, Mankin HJ. Recurrence of giant-cell tumors of the long bones after curettage and packing with cement. J Bone Joint Surg Am. 1994; 76:1827–33.

9. Turcotte RE, Wunder JS, Isler MH, et al. Giantcell tumor of long bone: a Canadian sarcoma group study. Clin Orthop. 2002; 397:248–58.

10. Blackley HR, Wunder JS, Davis AM, White LM, Kandel R, Bell RS. Treatment of giant-cell tumors of long bones with curettage and bone grafting. J Bone Joint Surg Am. 1999; 81:811.

11. Dahlin DC, Cupps RE, Johnson Jr EW. Giantcell tumor: a study of 195 cases. Cancer. 1970; 25:1061–70.

12. Scully SP, Mott MP, Temple HT, O'keefe RJ, O'Donnell RJ, Mankin HJ. Late recurrence of giant-cell tumor of bone: a report of four cases. J Bone Joint Surg Am. 1994; 76:1231–3.

13. Bini SA, Gill K, Johnston JO. Giantcell tumor of bone: Curettage and cement reconstruction. Clin Orthop. 1995; 321:245–50.

14. Fraquet N, Faizon G, Rosset P, Phillipeau JM, Waast D, Gouin F. Long bones giant cells tumors: treatment by curettage and cavity fillng cementation. Orthop Traumatol Surg Res. 2009; 95:402–6.

15. Ayerza MA, Aponte-Tinao LA, Farfalli GL, Restrepo CA, Muscolo DL. Joint preservation after extensive curettage of knee giant cell tumors. Clin Orthop Relat Res. 2009; 467:2845–51.

16. Weber KL. What's new in musculoskeletal oncology. J Bone Joint Surg Am. 2005; 87:1400–10.