J Clin Neurol.  2011 Mar;7(1):43-46. 10.3988/jcn.2011.7.1.43.

Seropositive Myasthenia Gravis Associated with Small-Cell Lung Carcinoma

  • 1Department of Neurology, Keiyo University Medical School, Tokyo, Japan.
  • 2Department of Neurology, Soonchunhang University Medical School, Cheonan, Korea.
  • 3Department of Neurology, University of Alabama at Birmingham, Veterans Medical Center, Birmingham, Alabama, USA. shinjoh@uab.edu


Lambert-Eaton myasthenic syndrome is well known to be a classical paraneoplastic syndrome of small cell lung carcinoma (SCLC). Three cases of seronegative myasthenia gravis (MG) and SCLC were previously reported. CASE REPORT: A 65-year-old man developed a severe progressive respiratory failure with clinical features of MG. Tests showed a decremental response in the repetitive nerve stimulation test, abnormal single-fiber electromyography, and positive acetylcholine receptor antibody. SCLC was confirmed by the lung biopsy.
This case represents the first case of seropositive MG and SCLC.


acetylcholine receptor antibody; myasthenia gravis; small cell lung cancer
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