J Korean Geriatr Psychiatry.  2011 Dec;15(2):70-75.

The Prevalence and Severity of Neuropsychiatric Symptoms in Alzheimer's Disease and Subcortical Vascular Dementia : the CREDOS Study

Affiliations
  • 1Jeju Mental Sanatorium, Jeju, Korea.
  • 2Department of Psychiatry, Gyeonggi Provincial Hospital for the Elderly, Yongin, Korea.
  • 3Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. sykim@amc.seoul.net
  • 4Department of Psychiatry, Sungkyunkwan University, College of Medicine, Seoul, Korea.
  • 5Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
  • 6Department of Neurology, Seoul National University, College of Medicine, Seoul, Korea.
  • 7Department of Neurology, Konkuk University, College of Medicine, Seoul, Korea.
  • 8Department of Neurology, Sungkyunkwan University, College of Medicine, Seoul, Korea.

Abstract


OBJECTIVES
This study aimed to compare the prevalence and severity of clinically relevant neuropsychiatric symptoms between subjects with Alzheimer's disease (AD) and subcortical vascular dementia (SVD).
METHODS
The CREDOS (Clinical Research for Dementia Of South Korea) is a multicenter longitudinal cohort study organized to evaluate the long-term outcome of dementia patients. Out of a total 3,080 subjects, we selected 1,392 AD subjects and 247 SVD subjects with mild to moderate levels of dementia. The Neuropsychiatric Inventory (NPI) and Clinical Dementia Rating Scale (CDR), and CDR sum of box scores were used for evaluation.
RESULTS
After controlling for severity of dementia and duration of education, SVD subjects had relatively more symptoms of apathy compared to AD subjects (OR : 1.397, p=0.025). SVD subjects also had relatively higher NPI composite scores in the apathy domain compared to AD subjects, after controlling for severity of dementia, age and duration of education (F=7.88, p=0.01). Subjects with moderate levels of dementia had more frequent and severe neuropsychiatric symptoms compared to those with mild dementia.
CONCLUSION
Symptoms of apathy were more prevalent and severe in subjects with SVD, compared to subjects with AD.

Keyword

Alzheimer disease; Subcortical vascular dementia; Apathy; Agitation
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