Korean J Dermatol.  2011 Dec;49(12):1087-1092.

Cryoglobulinemia Associated with Gastric Diffuse Large B Cell Lymphoma

• Jeon SY
• Ko DY
• Hong JW
• Lee KY
• Kim KH
• Song KH

Abstract

Cryoglobulinemia, first described by Wintrobe and Buell in 1933, is characterized by the presence of serum immunoglobulins that precipitate below 37degrees C and that dissolve on rewarming. Although the actual mechanism of cryoprecipitation and the etiology of cryoglobulinemia remains obscure, it is frequently associated with other systemic diseases, such as hepatitis C virus (HCV) infection, multiple myeloma, Sjogren's syndrome, B cell lymphoma, and systemic lupus erythematosus. No cases of cryoglobulinemia associated with B cell lymphoma have ever been published in the Korean medical literature, and few such cases have been reported in other countries. Herein, we report on a rare and interesting case of cryoglobulinemia developed in a patient with gastric diffuse large B cell lymphoma.

Keyword

B cell; Cryoglobulinemia; Lymphoma

MeSH Terms

Cryoglobulinemia
Hepacivirus
Humans
Immunoglobulins
Lupus Erythematosus, Systemic
Lymphoma
Lymphoma, B-Cell
Multiple Myeloma
Rewarming
Sjogren's Syndrome
Immunoglobulins