J Korean Surg Soc.  2011 Dec;81(6):419-422. 10.4174/jkss.2011.81.6.419.

Adenocarcinoma derived from gastric hamartomatous polyps

• Oh SJ
• Oh CA
• Kim DH
• Choi MG
• Noh JH
• Sohn TS
• Kim KM
• Bae JM
• Kim S

• KMID: 1445772
• DOI: http://doi.org/10.4174/jkss.2011.81.6.419

Abstract

Most hamartomatous polyps in the stomach occur in patients with adenomatous polyposis coli and dysplasia. The authors report a case of a 57-year-old man without prior history of polyposis coli who presented with adenocarcinomas derived from hamartomatous polyps in the stomach. The patient underwent a radical subtotal gastrectomy with Billroth I anastomosis. Pathology revealed adenocarcinomas with moderate differentiation without evidence of lymph node metastasis in 60 nodes. We report a case of gastric cancers arising from de novo gastric hamartomatous polyps.

Keyword

Hamartoma; Stomach neoplasms; Gastrectomy

MeSH Terms

Adenocarcinoma
Adenomatous Polyposis Coli
Gastrectomy
Gastroenterostomy
Hamartoma
Humans
Lymph Nodes
Middle Aged
Neoplasm Metastasis
Polyps
Stomach
Stomach Neoplasms

Figure

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  Fig. 1 (A) Esophagogastroduodenoscopy showed three lesions. On greater curvature side of antrum, 1 cm and 3 cm sized lesions. (B) 6 cm sized pedunculated polypoid masson greater curvature side of antrum.

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  Fig. 2 (A) Upper gastrointestinal series showed 6 cm sized, large polypoid mass and (B) Another two 2.5 cm sized polypoid masses in antrum.

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  Fig. 3 The specimen showed two lesions. On the lower body and lesser curvature, 6 × 5 cm sized pedunculated polypoid lesion (I) and on the antrum and greater curvature, a 5.5 × 2 cm sized irregular shaped elevated mass (II).

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  Fig. 4 (A) There was ramifying proliferation of smooth muscle bundles within lamina propria, suggesting hamartomatous polyp (H&E, ×10). (B) Higher magnification showing adenocarcinoma, proliferation of smooth muscle bundles and foveolar epithelium. (H&E, ×50). (C) Epstein-Barr virus (EBV)-encoded RNA in situ hybridization of gastric carcinoma (EBV in situ hybridization, ×400).

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