J Korean Diabetes.  2013 Jun;14(2):98-101. 10.4093/jkd.2013.14.2.98.

A Case of Insulinoma with Hypoglycemic Encephalopathy

• Kim KH
• Kim ES
• Park CS
• Ko MK
• Byun SS
• Hong JM
• Lee MY
• Nam-Goong
• Kim YI
• Na YW
• Choi HJ
• Kwon JH

• KMID: 1430845
• DOI: http://doi.org/10.4093/jkd.2013.14.2.98

Abstract

A 47-year-old male with recurrent abnormal behavior for ten years was referred to our clinic. He was diagnosed with insulinoma and cognitive dysfunction. Persistent hypoglycemia leads to a high risk of cognitive dysfunction in diabetic patients. However, cognitive dysfunction associated with insulinoma is rare. In this case study, cognitive dysfunction was confirmed by neurological testing.

Keyword

Insulinoma; Hypoglycemia; Encephalopathy

MeSH Terms

Humans
Hypoglycemia
Insulinoma
Male

Figure

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  Fig. 1. (A) Pancreas computed tomography scan showing an enhanced 8-mm nodule in the superior aspect of the pancreas body. (B) Transhepatic portal venous sampling revealed an elevated serum insulin level (662.7 μU/mL) in the body of the pancreas.

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  Fig. 2. Microscopically, the tumor showed a solid, trabecular, and gyriform growth pattern. The tumor cells had small and relatively uniform nuclei with a granular cytoplasm. Hyalinized stroma with calcification are seen (H&E, x200).

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