Korean J Nephrol.  2006 Sep;25(5):835-839.

A Case of Neuroleptic Malignant Syndrome (NMS) with Myoglobulinemic Acute Renal Failure and Lithium Intoxication due to Lithium-olanzapine Combination

• Oh WT
• Maeng CH
• Park MN
• Choi SY
• Jeong KH
• Moon JY
• Lee TW
• Ihm CG
• Lee SH

Abstract

We report a patient developed neuroleptic malignant syndrome (NMS) with myoglobulinemic acute renal failure and lithium intoxication due to lithium-olanzapine combination, who was successfully treated by hemodiafiltration. A 34-year-old woman with a 14-year history of bipolar disorder had been treated with lithium-olanzapine during last four days. She was admitted to our hospital for muscular rigidity, hyperthermia and altered consciousness. On admission, rhabdomyolsis was demonstratd by biochemical methods and serum level of lithium was 3.78 mEq/L which was far above toxic level. After the diagnosis of NMS with acute renal failure and lithium intoxication, olanzapine and lithium were discontinued and conservative measures and continuous venovenous hemodiafiltration were instituted. She recovered without any neurologic sequelae.

Keyword

Neuroleptic malignant syndrome (NMS); Acute renal failure; Lithium intoxication

MeSH Terms

Female
Humans
Neuroleptic Malignant Syndrome