Korean J Gastroenterol.  2012 Mar;59(3):205-210. 10.4166/kjg.2012.59.3.205.

Transient Lower Esophageal Sphincter Relaxation and the Related Esophageal Motor Activities

• Han SH
• Hong SJ

• KMID: 1245204
• DOI: http://doi.org/10.4166/kjg.2012.59.3.205

Abstract

Transient lower esophageal sphincter (LES) relaxation (TLESR) is defined as LES relaxation without a swallow. TLESRs are observed in both of the normal individuals and the patients with gastroesophageal reflux disorder (GERD). However, TLESR is widely considered as the major mechanism of the GERD. The new equipments such as high resolution manometry and impedance pH study is helped to understand of TLESR and the related esophageal motor activities. The strong longitudinal muscle contraction was observed during development of TLESR. Most of TLESRs are terminated by TLESR related motor events such as primary peristalsis and secondary contractions. The majority of TLESRs are associated with gastroesophageal reflux. Upper esophageal sphincter (UES) contraction is mainly associated with liquid reflux during recumbent position and UES relaxation predominantly related with air reflux during upright position. The frequency of TLESR in GERD patients seems to be not different compared to normal individuals, but the refluxate of GERD patients tend to be more acidic during TLESR.

Keyword

Transient high resolution manometry; Gastroesophageal reflux

MeSH Terms

Esophageal Sphincter, Lower/*physiology
Esophagogastric Junction/physiology
Esophagus/*physiology
Gastroesophageal Reflux/*physiopathology
Humans
Muscle Relaxation/physiology