Korean J Gastroenterol.  2003 Jun;41(6):519-522.

Primary Non-Hodgkin's Lymphoma of the Spleen Associated with Hepatitis B Virus Infection

• Bae SH
• Park SH
• Ryoo HM
• Kim HG
• Cho CH
• Lee JL
• Lee KH
• Hyun MS

Abstract

The incidence of primary splenic lymphoma is less than 1% of all non-Hodgkin's lymphoma. Lymphotrophism of hepatitis C virus may play a important role in the development of primary splenic lymphoma. However, there is no report about primary splenic lymphoma associated with hepatitis B virus infection. We present two cases of primary splenic lymphoma associated with hepatitis B virus infection. They suffered from left upper quadrant abdominal pain and underwent diagnostic splenectomy. In case 1, the spleen had a 10 x 10 x 9 cm lobulated tumor mass that replaced the splenic parenchyma. In case 2, the spleen contained two lobulated macronodular white tumors, measuring 3 x 2 cm and 2 x 2 cm. Splenic tumors were confirmed pathologically to be intermediate and high grade of B cell lymphoma. The patients received combination chemotherapy with CHOP. They are still alive without recurrence 23 months and 15 months after splenectomy.

Keyword

Primary splenic lymphoma; Hepatitis B virus; Lymphoma; non-Hodgkin; Splenectomy

MeSH Terms

Incidence