Korean J Ophthalmol.  2009 Mar;23(1):43-45. 10.3341/kjo.2009.23.1.43.

Granular Cell Tumor of The Inferior Rectus Muscle

• Poyraz CE
• Kiratli H
• Soylemezoglu F

• KMID: 1115651
• DOI: http://doi.org/10.3341/kjo.2009.23.1.43

Abstract

A 53-year-old woman complaining of vertical diplopia, presented with a localized swelling in the right lower lid. Magnetic resonance imaging studies demonstrated a relatively well-defined mass in the inferior rectus with similar signal characteristics to the muscle. Excisional biopsy of the mass revealed granular cell tumor composed of S-100 positive cells with acidophilic granular cytoplasm and a peripheral lymphocytic infiltration. Granular cell tumor, which is very rare in the orbit, should be considered in the differential diagnosis of tumors adjacent to or within the extraocular muscles, particularly in the inferior orbit.

Keyword

Extraocular muscle; Granular cell tumor; Inferior rectus; Magnetic resonance imaging; Orbit

MeSH Terms

Biopsy
Diagnosis, Differential
Eye Neoplasms/*pathology
Female
Follow-Up Studies
Granular Cell Tumor/*pathology
Humans
Magnetic Resonance Imaging
Middle Aged
Muscle Neoplasms/*pathology
Oculomotor Muscles/*pathology

Figure

• 

  Fig. 1 (A) Sagittal T1-weighted MRI view of the right orbit showing the inferiorly located mass. (B) In this coronal T2-weighted MRI frame, distinction between the tumor and the inferior rectus muscle cannot be made.

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  Fig. 2 (A) The tumor consists of nests of polygonal cells with prominent round to oval nuclei in a collagenized stroma with a fascicular development pattern (H&E, original magnification ×60). (B) Positive staining with periodic acid-Schiff reagent (original magnification ×100). (C) Tumor cells stain strongly positive for S-100 protein (S-100, original magnification ×100).

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