J Vet Sci.  2005 Sep;6(3):247-250.

Immunosuppression by T regulatory cells in cows infected with Staphylococcal superantigen

  • 1Animal Health Research, LG Life Sciences Ltd., Daejeon 305-380, Korea.
  • 2Department of Microbiology, Molecular Biology and Biochemistry, University of Idaho, Moscow, ID 83844, USA.
  • 3Department of Immunology, The Scripps Research Institute, IMM-32, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
  • 4Department of Veterinary Microbiology and Pathology and.
  • 5Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA.
  • 6Department of Microbiology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Seoul 151-742, Korea.yhp@snu.ac.kr.


Our recent study has provided that the in vitro SEC-induced proliferation of bovine T cells is preceded by a period of a non-proliferative immunoregulation of T cells that may be associated with cytokine production regulated by type 1 or type 2 T cells. Inversion of CD4+:CD8+ T cell ratio and induction of CD8+T cells with immunoregulatory activity could increase the probability of intracellular survival of Staphylococcus aureus (S. aureus). The increase of activated CD8+(ACT2+ BoCD8+) T cells in cows with mastitis caused by S. aureus may be associated with immune-regulatory function in the bovine mammary gland. The difference and similarity between bovine activated CD8+ T cells (CD8+ CD26+)and well-established human CD4+ CD25+ T regulatory (Tr)cells may help to reveal their unique immune regulatory system in the host infected with S. aureus.


bovine mastitis; CD4 + CD25 + T regulatory cells; immunosuppression; Staphylococcus aureus; superantigens
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