Korean J Radiol.  2007 Dec;8(6):545-547. 10.3348/kjr.2007.8.6.545.

Imaging Findings of Central Nervous System Vasculitis Associated with Goodpasture's Syndrome: a Case Report

• Kim JY
• Ahn KJ
• Jung JI
• Jung SL
• Kim BS
• Hahn ST

• KMID: 1089443
• DOI: http://doi.org/10.3348/kjr.2007.8.6.545

Abstract

Glomerulonephritis and pulmonary hemorrhage are features of Goodpasture's syndrome. Goodpasture's syndrome accompanied with central nervous system (CNS) vasculitis is extremely rare. Herein, we report a rare case of CNS vasculitis associated with Goodpasture's syndrome in a 34-year-old man, who presented with a seizure and sudden onset of right sided weakness. He also had recurrent hemoptysis of one month's duration. Goodpasture's syndrome is histologically diagnosed by intense linear deposits of IgG along the glomerular basement membrane in both renal and lung tissues.

Keyword

Brain, vasculitis; Lung, hemorrhage; Magnetic resonance (MR)

MeSH Terms

Adult
Anti-Glomerular Basement Membrane Disease/complications/*diagnosis/therapy
Anti-Inflammatory Agents/administration & dosage
Brain/*pathology
Contrast Media/administration & dosage
Diagnosis, Differential
Fluorescent Antibody Technique
Hemoptysis/etiology
Humans
Image Enhancement/methods
Immunoglobulin G/immunology
Kidney/ultrasonography
Lung/pathology/*radiography
Magnetic Resonance Imaging
Male
Methylprednisolone/administration & dosage
Muscle Weakness/etiology
Plasmapheresis
Rare Diseases
Seizures/etiology
Tomography, X-Ray Computed
Vasculitis, Central Nervous System/*diagnosis/etiology/therapy

Figure

• 

  Fig. 1 Lung CT showing multifocal ground-glass opacities in both lungs, suggesting a pulmonary hemorrhage.

• 

  Fig. 2 A-C. The brain MR T2-weighted axial images showing multifocal small nodular, high signal intensities in the bilateral cerebellar hemispheres, right frontal and left parietal cortices. D-F. Contrast enhanced T1-weighted axial images showing leptomeningeal enhancement along both parasagittal regions and cerebellar hemispheres.

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