Korean J Radiol.  2011 Apr;12(2):252-255. 10.3348/kjr.2011.12.2.252.

Diffuse Interstitial Infiltrative Lung Metastasis of Malignant Melanoma: a Case Report

• Shin NY
• Hong YJ
• Kim AH
• Shim HS
• Nam JE
• Lee HJ
• Kim MJ

• KMID: 1088572
• DOI: http://doi.org/10.3348/kjr.2011.12.2.252

Abstract

A diffuse interstitial infiltrative pattern of lung metastasis in a patient with malignant melanoma is rare and can be confused with benign conditions such as pulmonary edema or drug-induced pneumonitis. We experienced a case of diffuse interstitial infiltrative lung metastasis in malignant melanoma in a 37-year-old man. This case was confirmed by a transbronchial lung biopsy. We herein describe the findings on CT and positron emission tomography scan.

Keyword

Malignant melanoma; Lung; Metastasis; Interstitial disease

MeSH Terms

Adult
Biopsy
Diagnosis, Differential
Fatal Outcome
Humans
Lung Neoplasms/diagnosis/*secondary
Lymphatic Metastasis
Male
Melanoma/diagnosis/*secondary
Positron-Emission Tomography
Radiography, Thoracic
Skin Neoplasms/*pathology
Tomography, X-Ray Computed

Figure

• 

  Fig. 1 38-year-old man with diffuse interstitial infiltrative lung metastasis of malignont melanoma. A. Chest radiograph shows diffuse reticulonodular opacities in both of lungs with bilateral pleural effusions. B. Chest CT image (lung window) demonstrates intralobular interstitial thickenings and areas of ground-glass opacity with bilateral pleural effusions. C-E. Follow-up FDG PET/CT scan two months later shows extensive intralobular interstitial thickenings and diffuse areas of ground-glass opacity with bilateral pleural effusions on contrast-enhanced CT image (lung window) (C) and diffusely increased FDG uptake in both lungs with metastatic LNs in right chest wall, left neck, and retroperitoneum on PET image (D) CT image shows irregular narrowing of inferior vena cava (white arrow), suggesting invasion of inferior vena cava by metastatic aortocaval lymph node (black arrow) (E). F. Photomicrographs of histologic specimens show that tumor cells predominantly infiltrates in alveolar capillaries and interstitium. Tumor cells are round to oval in shape with enlarged nuclei and plump cytoplasm. G. Immunohistochemical stain for HMB-45 is positive for tumor cells.

Reference

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