Yonsei Med J.  2011 Nov;52(6):1044-1047. 10.3349/ymj.2011.52.6.1044.

Frontal Sinus Lymphoma Presenting As Progressive Multiple Cranial Nerve Palsy

• Kim K
• Kim MJ
• Ahn S
• Bae SY
• Kim WS
• Yoon JH

• KMID: 1058831
• DOI: http://doi.org/10.3349/ymj.2011.52.6.1044

Abstract

Primary frontal sinus lymphoma is a very uncommon disease. In all the previously reported cases, the presenting symptoms have been due to the tumor mass effect. We present an unusual case report of an immunocompetent patient who presented with facial palsy, and then progressively developed other cranial nerve palsies over several months. He was later diagnosed with diffuse large B cell lymphoma originating from the frontal sinus. The patient underwent chemotherapy, but eventually had to receive autologous peripheral blood stem cell transplantation. He is currently disease-free. The clinical course, diagnostic workup, and therapeutic outcome are described.

Keyword

Frontal sinus; lymphoma; multiple cranial nerve palsy

MeSH Terms

Adult
Cranial Nerve Diseases/*diagnosis/pathology
Frontal Sinus/*pathology
Humans
Lymphoma/*diagnosis/pathology
Male

Figure

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  Fig. 1 Coronal MRI showing a mass in the frontal sinus. Left panel, T2 weighted image. Right panel, contrast-enhanced T1 weighted image. MRI, magnetic resonance image.

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  Fig. 2 Pathological results of intranasal biopsy of frontal sinus. (A) Hematoxylin and eosin stain, original magnification ×100. (B) Hematoxylin and eosin stain, ×400. (C) CD20 stain, ×200. (D) Bcl-2 stain, ×200. (E) Ki-67 stain, ×200.

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