Korean J Ophthalmol.  2011 Jun;25(3):161-165. 10.3341/kjo.2011.25.3.161.

Multifocal Electroretinogram Findings after Intravitreal Bevacizumab Injection in Choroidal Neovascularization of Age-Related Macular Degeneration

Affiliations
  • 1Department of Ophthalmology, Soonchunhyang University College of Medicine, Bucheon, Korea. yhohn@schmc.ac.kr

Abstract

PURPOSE
To evaluate the changes in multifocal electroretinogram (mfERG) and optical coherence tomography (OCT) after intravitreal bevacizumab injection in the treatment of age-related macular degeneration (AMD).
METHODS
Twenty-one eyes with choroidal neovascularization secondary to AMD were studied before and after intravitreal bevacizumab injection for best corrected visual acuity (BCVA), OCT, and mfERG.
RESULTS
The BCVA improved, while central macular thickness and total macular volume in OCT decreased after intravitreal bevacizumab injection (p = 0.03, 0.01, and 0.01, respectively). In mfERG, the amplitude of P1, and implicit time of P1 and N1 indicated a statistically significant improvement of retinal response after intravitreal bevacizumab injection.
CONCLUSIONS
There is a potential role for mfERG in evaluating the effect on retinal function of intravitreal bevacizumab injection.

Keyword

Age-related macular degeneration; Bevacizumab; Choroidal neovascularization; Multifocal electroretinogram; Optical coherence tomography
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