- The Expression of the Bcl-2 Family Proteins in Thyroid Neoplasms
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Ahn IM, Kim ES, Hong SJ, Gong KY, Lee TJ, Kim JY, Kim SB, Kim SH
- KMID: 2331109
- J Korean Soc Endocrinol.
- 1998 Sep;13(3):359-365.
BACKGROUND: Proteins of the Bcl-2 family are intracellular membrane-associated proteins that regulate programmed cell death either positively or negatively by as yet unknown mechanism. Bcl-2 family proteins have an antiapoptotic... -
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- Apoptosis and Expression of bcl-2, bax in the Cyclic Human Endometrium
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Suh CS, Moon SY
- KMID: 2075934
- Korean J Obstet Gynecol.
- 1999 Nov;42(11):2446-2457.
OBJECTIVE: To understand the regulatory mechanism of apoptosis by pro- and anti-apoptotic genes in the cyclic human endometrium. METHODS: Each case of endometrial status was classified by Noyes criteria, and... -
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- Bax Protein in Cancer Treatment
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Choi JH
- KMID: 2184949
- J Korean Med Assoc.
- 2007 Nov;50(11):1016-1022.
- doi: 10.5124/jkma.2007.50.11.1016
Apoptosis is the major mechanism of cancer cell death by chemotherapy as well as radiation. Bax is a critical downstream mediator of apoptosis which belonged to the Bcl-2 family, and... -
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- Apoptosis of Prostate Cancer by Inhibition of Bcl-xL Expression
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Kwak C, Jeong H, Kim JH, Lee ES, Lee SE
- KMID: 2293491
- Korean J Urol.
- 2004 May;45(5):463-471.
PURPOSE: In this study, we evaluated in vitro whether the anti-sense transfection that was targeted against Bcl-xL would induce cytotoxicity via apoptosis in prostate cancer cells. MATERIALS AND METHODS: cDNA of... -
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- Immunohistochemical Expression of Bcl-2, Bcl-xL, Bax, p53 Proteins in Gastric Adenoma and Adenocarcinoma
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Lee DS, Kang SB, Baek JT, Nam SW, Lee KM, Ahn BM, Lee EH, Han SW, Chung IS
- KMID: 772786
- Korean J Gastroenterol.
- 2005 Jun;45(6):394-400.
BACKGROUND/AIMS: The aim of this study was to investigate the immunohistochemical expression of bcl-2, bcl-xL, bax, and p53 proteins according to the pathological parameters such as grade of dysplasia,... -
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- Response for radiation therapy and p53, bcl-2 and bax protein expressions in uterine cervical carcinoma
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Lee ED, Lee KB, Suk WI, Choi JR, Lee JM, Park CY, Ha SY, Chan LK
- KMID: 2129003
- Korean J Obstet Gynecol.
- 2002 Oct;45(10):1794-1799.
OBJECTIVE: To evaluate the relationship between p53, bcl-2 and bax protein expressions and clinical response to radiation therapy in patients with cervical squamous cell carcinoma and possibility of using them... -
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- bcl-2 and bax Expression in Prostate Carcinoma
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Song YJ, Yang DY, Lee SH, Nam ES, Kim SY, Kim H, Park HW
- KMID: 2290346
- Korean J Urol.
- 1999 Jun;40(6):709-714.
PURPOSE: Proteins encoded by bcl-2 family as regulators of apoptosis appear to have significant cellular effects such that when abnormally expressed, they may render certain cells more susceptible to aberrant... -
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- BCL-2 and BAX Expression in Normal Human Endometrium
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Hong SO, Lee BS, Yang WI, Lee JS, Cha DH, Cho YS, Kim JY, Park KH, Cho DJ, Song CH
- KMID: 2085139
- Korean J Fertil Steril.
- 2000 Sep;27(3):245-251.
OBJECTIVE: To investigate the distribution of BCL-2, BAX proteins and DNA fragmented cells in the normal human endometrium during at each menstrual cycle in order to find out whether apoptosis... -
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- Expression of Bcl-2 and Bax in cis-Diamminedichloroplatinum (II)-Resistant Bladder Cancer Cell Lines
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Song C, Kang TJ, You DS, Hong JH, Ahn HJ
- KMID: 2293492
- Korean J Urol.
- 2004 May;45(5):472-477.
PURPOSE: Development of drug resistance has been the major obstacle in cis-Diamminedichloroplatinum (II) (cisplatin)-based combination chemotherapy in the treatment of advanced bladder cancer for which a variety of mechanisms has... -
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- The Apoptosis and Expression of Bcl-2, Bcl-xS, Bax Proteins in Fetal Brain after Treating Pregnant Mice with Endotoxin
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Cho SM, Kim SS, Hwang YS
- KMID: 1946279
- J Korean Pediatr Soc.
- 2000 Jan;43(1):97-104.
PURPOSE: Apoptosis is active cell death which plays an important role in developing normal tissues. Various conditions such as genetic defects, drugs, ischemia or infections are known to induce apoptosis.... -
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- Effect of Synthetic Tyrosine Kinase Inhibitor(ZM260603) on the Growth of Prostate Cancer Cell Lines: Differences According to Androgen Dependency and Bcl-2 Expression
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Hong SJ, Chung HJ, Lee DH, Cho ES
- KMID: 2290400
- Korean J Urol.
- 1999 Nov;40(11):1487-1492.
PURPOSE: We determined the effect of tyrosine kinase inhibitor(TKI), ZM260603 on the growth of prostate cancer cell lines. MATERIALS AND METHODS: Using the synthetic TKI, ZM260603, cytotoxicity test and cell... -
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- Apoptosis of Prostate Cancer by Bax Gene Expression
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Kwak C, Jin RJ, Ku JH, Jeong H, Lee ES, Lee SE, Lee CW
- KMID: 2293555
- Korean J Urol.
- 2003 Sep;44(9):916-923.
PURPOSE: To evaluate the antitumor effect of the proapoptotic Bax gene in prostate cancer cells, in vitro, using a plasmid vector expressing the human Bax gene. MATERIALS AND METHODS: cDNA of... -
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- Induction of Apoptosis of Bladder Cancer Cells by Zinc-Citrate Compound
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Hong SH, Choi YS, Cho HJ, Lee JY, Hwang TK, Kim SW
- KMID: 2316135
- Korean J Urol.
- 2012 Nov;53(11):800-806.
PURPOSE: Zinc is one of the trace minerals in the body and is known to have an anticancer effect by inducing apoptosis in prostate cancer. We aimed to investigate the... -
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- Expression of Survivin, HSP90, Bcl-2 and Bax Proteins in N-butyl-N-(4-hydroxybutyl)nitrosamine-induced Rat Bladder Carcinogenesis
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Lee SD, Park SW, Hong SA, Kwon GY, Lee TJ
- KMID: 1640303
- Korean J Pathol.
- 2006 Oct;40(5):333-338.
BACKGROUND: Survivin belongs to the inhibitor of apoptosis family, and it has recently been found to be expressed in most solid tumors. Therefore, its expression is suggested to have prognostic... -
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- Synergistic Apoptotic Effect of Combination Treatment with Troglitazone and COX-2 Inhibitor in Glioma Cells
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Kim KR, Park MY, Park HS, Jang KY, Moon WS, Lee DG, Kang MJ
- KMID: 1521688
- Korean J Pathol.
- 2007 Feb;41(1):1-6.
BACKGROUND: The use of troglitazone (a PPARgamma ligand) and COX-2 inhibitor have been intensively studied for inhibition of tumor growth in cancer treatment, but the anti-tumor effect with a combination... -
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- Up-regulation of Intragraft Gene Expression of Bcl-xL in Response to Injuries to Renal Allograft
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Chae DW, Oh KH, Shin JH, Yoon HJ, Nam ES, Yoon JW, Kim KH, Kim YS, Kim SG
- KMID: 1989746
- Korean J Nephrol.
- 2001 May;20(3):403-412.
BACKGROUND: Bcl-xL and bax act as checkpoints of the apoptotic cell death. Although apoptosis is one of major mechanism of cell death in renal allografts inflicted by various events, the... -
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- Induction of the Intrinsic Apoptotic Pathway by 3-Deazaadenosine Is Mediated by BAX Activation in HL-60 Cells
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Lee SY, Ko KW, Kang WK, Choe YJ, Kim YH, Kim IK, Kim J, Kim HS
- KMID: 2071713
- Korean J Physiol Pharmacol.
- 2010 Dec;14(6):407-412.
- doi: 10.4196/kjpp.2010.14.6.407
3-Deazaadenosine (DZA), a potent inhibitor of S-adenosylhomocysteine hydrolase, was previously proposed to induce intrinsic apoptosis in human leukemic cells. In the present study, we analyzed the mechanism underlying the DZA-induced... -
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- Amygdalin Regulates Apoptosis and Adhesion in Hs578T Triple-Negative Breast Cancer Cells
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Lee HM, Moon A
- KMID: 2170542
- Biomol Ther.
- 2016 Jan;24(1):62-66.
- doi: 10.4062/biomolther.2015.172
Amygdalin, D-mandelonitrile-beta-D-glucoside-6-beta-glucoside, belongs to aromatic cyanogenic glycoside group derived from rosaceous plant seed. Mounting evidence has supported the anti-cancer effects of amygdalin. However, whether amygdalin indeed acts as an anti-tumor... -
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- Mycophenolic acid mediated mitochondrial membrane potential transition change lead to T lymphocyte apoptosis
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Choi SJ, Lee HK, Kim NH, Chung SY
- KMID: 1445743
- J Korean Surg Soc.
- 2011 Oct;81(4):235-241.
- doi: 10.4174/jkss.2011.81.4.235
PURPOSE: This study demonstrated that apoptosis induced by mycophenolic acid (MPA) is mediated by mitochondrial membrane potential transition (MPT) changes in Jurkat cells. METHODS: Cell viability and MPT changes were measured... -
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- Expression of 14-3-3 proteins and Bax in the placenta of preeclampsia
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Park JK, Kim SI, Paik WY
- KMID: 2077758
- Korean J Obstet Gynecol.
- 2007 Jun;50(6):858-864.
OBJECTIVE: Purpose of our study was to examine the expression level of 14-3-3 proteins and Bcl-2 family and to estimate the interaction between 14-3-3 proteins and Bcl-2 family in normal... -
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