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Cellular uptake of magnetic nanoparticle is mediated through energydependent endocytosis in A549 cells

Kim JS, Yoon TJ, Yu KN, Noh MS, Woo M, Kim BG, Lee KH, Sohn BH, Park SB, Lee JK, Cho MH

Biocompatible silica-overcoated magnetic nanoparticles containing an organic fluorescence dye, rhodamine B isothiocyanate (RITC), within a silica shell [50 nm size, MNP@SiO2(RITC)s] were synthesized. For future application of the MNP@SiO2(RITC)s into...
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Acute Pulmonary Toxicity and Body Distribution of Inhaled Metallic Silver Nanoparticles

Kwon JT, Minai-Tehrani A, Hwang SK, Kim JE, Shin JY, Yu KN, Chang SH, Kim DS, Kwon YT, Choi IJ, Cheong YH, Kim JS, Cho MH

  • KMID: 2052548
  • Toxicol Res.
  • 2012 Mar;28(1):25-31.
The purpose of this study was to determine the acute pulmonary toxicity of metallic silver nanoparticles (MSNPs, 20.30 nm in diameter). Acute pulmonary toxicity and body distribution of inhaled MSNPs...
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Serum immunoglobulin fused interferon-alpha inhibited tumor growth in athymic mice bearing colon 26 adenocarcinoma cells

Kim JS, Yu KN, Noh MS, Woo MA, Park SJ, Park JH, Hua J, Cho HS, Hwang SK, Lee ES, Chung YS, Choi IY, Kwon SC, Cho MH

Interferon (IFN) has therapeutic potential for a wide range of infectious and proliferative disorders. However, the half-life of IFN is too short to have a stable therapeutic effect. To overcome...
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Aerosol delivery of kinase-deficient Akt1 attenuates Clara cell injury induced by naphthalene in the lungs of dual luciferase mice

Minai-Tehrani A, Park YC, Hwang SK, Kwon JT, Chang SH, Park SJ, Yu KN, Kim JE, Shin JY, Kim JH, Kang B, Hong SH, Cho MH

Conventional lung cancer therapies are associated with poor survival rates; therefore, new approaches such as gene therapy are required for treating cancer. Gene therapies for treating lung cancer patients can...
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