- Ape1/Ref-1 Stimulates GDNF/GFR alpha1-mediated Downstream Signaling and Neuroblastoma Proliferation
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Kang MY, Kim KY, Yoon Y, Kang Y, Kim HB, Youn CK, Kim DH, Kim MH
- KMID: 1982567
- Korean J Physiol Pharmacol.
- 2009 Oct;13(5):349-356.
- doi: 10.4196/kjpp.2009.13.5.349
We previously reported that glial cell line-derived neurotropic factor (GDNF) receptor alpha1 (GFR alpha1) is a direct target of apurinic/apyrimidinic endonuclease 1 (Ape1/Ref-1). In the present study, we further analyzed... -
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- Inhibition of ERK1/2 by silymarin in mouse mesangial cells
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Youn CK, Cho SI, Lee MY, Jeon YJ, Lee SK
- KMID: 2371075
- Korean J Physiol Pharmacol.
- 2017 Jan;21(1):117-124.
- doi: 10.4196/kjpp.2017.21.1.117
The present study aimed to show that pro-inflammatory cytokines [tumor necrosis factor (TNF)-α, interferon (IFN)-γ, and interleukin (IL)-1β] synergistically induce the production of nitric oxide (NO) production in mouse mesangial... -
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- Silibinin Inhibits LPS-Induced Macrophage Activation by Blocking p38 MAPK in RAW 264.7 Cells
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Youn CK, Park SJ, Lee MY, Cha MJ, Kim OH, You HJ, Chang IY, Yoon SP, Jeon YJ
- KMID: 2170670
- Biomol Ther.
- 2013 Jul;21(4):258-263.
We demonstrate herein that silibinin, a polyphenolic flavonoid compound isolated from milk thistle (Silybum marianum), inhibits LPS-induced activation of macrophages and production of nitric oxide (NO) in RAW 264.7 cells.... -
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- Radicicol Inhibits iNOS Expression in Cytokine-Stimulated Pancreatic Beta Cells
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Youn CK, Park SJ, Li MH, Lee MY, Lee KY, Cha MJ, Kim OH, You HJ, Chang IY, Yoon SP, Jeon YJ
- KMID: 2285466
- Korean J Physiol Pharmacol.
- 2013 Aug;17(4):315-320.
- doi: 10.4196/kjpp.2013.17.4.315
Here, we show that radicicol, a fungal antibiotic, resulted in marked inhibition of inducible nitric oxide synthase (iNOS) transcription by the pancreatic beta cell line MIN6N8a in response to cytokine... -
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