- Stretch-activated K+ Channels in Rat Atrial Myocytes
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Youm JB
- KMID: 1607519
- Korean J Physiol Pharmacol.
- 2003 Dec;7(6):341-348.
Mechanical stimuli to the cardiac myocytes initiate many biochemical and physiological events. Stretch-activated cation channels have been suggested to mediate these events. In this study, cell-attached and inside-out excised-patch clamp... -
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- Protein Kinase C Activates ATP-sensitive Potassium Channels in Rabbit Ventricular Myocytes
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Kim N, Youm JB, Joo H, Kim H, Kim E, Han J
- KMID: 1600067
- Korean J Physiol Pharmacol.
- 2005 Aug;9(4):187-193.
Several signal transduction pathways have been implicated in ischemic preconditioning induced by the activation of ATP-sensitive K+ (KATP) channels. We examined whether protein kinase C (PKC) modulated the activity of... -
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- Role of Stretch-Activated Channels in Stretch-Induced Changes of Electrical Activity in Rat Atrial Myocytes
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Youm JB, Jo SH, Leem CH, Ho WK, Earm YE
- KMID: 1517035
- Korean J Physiol Pharmacol.
- 2004 Feb;8(1):33-41.
We developed a cardiac cell model to explain the phenomenon of mechano-electric feedback (MEF), based on the experimental data with rat atrial myocytes. It incorporated the activity of ion channels,... -
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- Differential Activation of Ras/Raf/MAPK Pathway between Heart and Cerebral Artery in Isoproterenol-induced Cardiac Hypertrophy
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Kim H, Kim N, Joo H, Youm JB, Park WS, Warda M, Kang S, Thu VT, Khoa TM, Han J
- KMID: 1600113
- Korean J Physiol Pharmacol.
- 2005 Oct;9(5):299-304.
Cardiac hypertrophy contributes an increased risk to major cerebrovascular events. However, the molecular mechanisms underlying cerebrovascular dysfunction during cardiac hypertrophy have not yet been characterized. In the present study, we... -
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- Potassium Currents in Isolated Deiters' Cells of Guinea Pig
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Chung JW, Nam EC, Kim WT, Youm JB, Leem CH
- KMID: 2285482
- Korean J Physiol Pharmacol.
- 2013 Dec;17(6):537-546.
- doi: 10.4196/kjpp.2013.17.6.537
Deiters' cells are the supporting cells in organ of Corti and are suggested to play an important role in biochemical and mechanical modulation of outer hair cells. We successfully isolated... -
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- A Computational Model of Cytosolic and Mitochondrial [Ca2+] in Paced Rat Ventricular Myocytes
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Youm JB, Choi SW, Jang CH, Kim HK, Leem CH, Kim N, Han J
- KMID: 1448927
- Korean J Physiol Pharmacol.
- 2011 Aug;15(4):217-239.
- doi: 10.4196/kjpp.2011.15.4.217
We carried out a series of experiment demonstrating the role of mitochondria in the cytosolic and mitochondrial Ca2+ transients and compared the results with those from computer simulation. In rat... -
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- Modeling of Arrhythmogenic Automaticity Induced by Stretch in Rat Atrial Myocytes
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Youm JB, Leem CH, Zhang YH, Kim N, Han J, Earm YE
- KMID: 1486109
- Korean J Physiol Pharmacol.
- 2008 Oct;12(5):267-274.
- doi: 10.4196/kjpp.2008.12.5.267
Since first discovered in chick skeletal muscles, stretch-activated channels (SACs) have been proposed as a probable mechano-transducer of the mechanical stimulus at the cellular level. Channel properties have been studied... -
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- Regional Differences in Mitochondrial Anti-oxidant State during Ischemic Preconditioning in Rat Heart
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Thu VT, Cuong DV, Kim N, Youm JB, Warda M, Park WS, Ko JH, Kim E, Han J
- KMID: 1512908
- Korean J Physiol Pharmacol.
- 2007 Apr;11(2):57-64.
Ischemic preconditioning (IPC) is known to protect the heart against ischemia/reperfusion (IR)-induced injuries, and regional differences in the mitochondrial antioxidant state during IR or IPC may promote the death or... -
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- Changes of Cytosolic Ca2+ under Metabolic Inhibition in Isolated Rat Ventricular Myocytes
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Kang S, Kim N, Joo H, Youm JB, Park WS, Warda M, Kim H, Cuong DV, Kim T, Kim E, Han J
- KMID: 1600112
- Korean J Physiol Pharmacol.
- 2005 Oct;9(5):291-298.
To characterize cytosolic Ca2+ fluctuations under metabolic inhibition, rat ventricular myocytes were exposed to 200microM 2, 4-dinitrophenol (DNP), and mitochondrial Ca2+, mitochondrial membrane potential (delta psi m), and cytosolic Ca2+... -
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- Mitochondrial pyruvate dehydrogenase phosphatase 1 regulates the early differentiation of cardiomyocytes from mouse embryonic stem cells
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Heo HJ, Kim HK, Youm JB, Cho SW, Song IS, Lee SY, Ko TH, Kim N, Ko KS, Rhee BD, Han J
- KMID: 2361541
- Exp Mol Med.
- 2016 Aug;48(8):e254.
- doi: 10.1038/emm.2016.70
Mitochondria are crucial for maintaining the properties of embryonic stem cells (ESCs) and for regulating their subsequent differentiation into diverse cell lineages, including cardiomyocytes. However, mitochondrial regulators that manage the... -
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- Combination treatment with 2-methoxyestradiol overcomes bortezomib resistance of multiple myeloma cells
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Song IS, Jeong YJ, Jeong SH, Heo HJ, Kim HK, Lee SR, Ko TH, Youm JB, Kim N, Ko KS, Rhee BD, Han J
- KMID: 2154269
- Exp Mol Med.
- 2013 Oct;45(10):e50.
Bortezomib is a proteasome inhibitor used for the treatment of relapsed/refractory multiple myeloma (MM). However, intrinsic and acquired resistance to bortezomib has already been observed in MM patients. In a... -
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- Effects of Mixed Herbal Extracts from Parched Puerariae Radix, Gingered Magnoliae Cortex, Glycyrrhizae Radix and Euphorbiae Radix (KIOM-79) on Cardiac Ion Channels and Action Potentials
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Park SJ, Choi KS, Shin DH, Kim JS, Jang DS, Youm JB, Choe H, Earm YE, Kim SJ
- KMID: 1779155
- J Korean Med Sci.
- 2009 Jun;24(3):403-412.
- doi: 10.3346/jkms.2009.24.3.403
KIOM-79, a mixture of ethanol extracts from four herbs (parched Puerariae radix, gingered Magnoliae cortex, Glycyrrhizae radix and Euphorbiae radix), has been developed for the potential therapeutic application to diabetic... -
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