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Identification of the associations between genes and quantitative traits using entropy-based kernel density estimation

Yee J, Park T, Park M

Genetic associations have been quantified using a number of statistical measures. Entropy-based mutual information may be one of the more direct ways of estimating the association, in the sense that...
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Comparison of Approval Process for Nonprescription Drugs in Different Countries

Kim JH, Yee J, Lee GY, Lee KE, Gwak HS

Nonprescription drugs have become increasingly important in Korean healthcare. By leveraging lower-cost drugs and reducing expenditure associated with fewer physician visits, the nonprescription segment can deliver tremendous value to individual...
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Genetic Association Analysis of Fasting and 1- and 2-Hour Glucose Tolerance Test Data Using a Generalized Index of Dissimilarity Measure for the Korean Population

Yee J, Kim Y, Park T, Park M

Glucose tolerance tests have been devised to determine the speed of blood glucose clearance. Diabetes is often tested with the standard oral glucose tolerance test (OGTT), along with fasting glucose...
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Clinical and Laboratory Features of Pediatric Patients with COVID-19: Systematic Review and Meta-analysis

Yoon HY, Cho YA, Yee J, Gwak HS, Han JM

Background: Although the identification of clinical and laboratory features in pediatric COVID-19 patients is essential in establishing an appropriate treatment plan, a systematic review and meta-analysis on the topic has...
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Factors Influencing Imatinib-Induced Hepatotoxicity

Han JM, Yee J, Cho YS, Gwak HS

Purpose Although imatinib-induced hepatotoxicity may aggravate the patient’s clinical condition and alter the treatment plan, the underlying mechanism of and factors influencing imatinibinduced hepatotoxicity have rarely been investigated. The purpose of...
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Fundamental Elements for Successful Performance of CT Colonography (Virtual Colonoscopy)

Park SH, Yee J, Kim SH, Kim YH

There are many factors affecting the successful performance of CT colonography (CTC). Adequate colonic cleansing and distention, the optimal CT technique and interpretation with using the newest CTC software by...
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Antinociceptive Effects of the Essential Oil of Ocimum Basilicum in Mice

Min SS, Han SH, Yee J, Kim C, Seol GH, Im JH, Kim HT, Lee KC, Kim HY, Lee MJ

BACKGROUND: The essential oil of Ocimum basilicum (EOOB) has a pleasant aroma and is known to have antimicrobial and insecticidal activities. In addition, it is used as a pain reliever...
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Population Pharmacokinetics of Cyclosporine after Hematopoietic Stem Cell Transplantation in Pediatric Patients

Cho SY, Yee J, Kang W, Kim JY, An SH, Gwak HS

BACKGROUND: Cyclosporine is an immunosuppressive agent used to treat and prevent graft versus host reaction (GVHR)-a complication associated with stem cell transplantation. This study aimed to develop a population pharmacokinetic...
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Analysis of Pharmacogenetic Information in Korea Drug Labels

Lee M, Kim S, Yee J, Gwak HS, Choi KH

Background: Pharmacogenomics is the study of how genetic mutations in patients affect their response to drugs. Pharmacogenomic studies aim to maximize drug effects and minimize adverse drug events. The Food...
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Do ACR TI-RADS scores demonstrate unique thyroid molecular profiles?

Xia R, Sun W, Yee J, Sheth S, Slywotzky C, Hodak S, Brandler TC

Purpose: The present study aimed to examine the molecular profiles of cytologically indeterminate thyroid nodules stratified by American College of Radiology Thyroid Imaging Reporting and Data System (TI-RADS) categories and...
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Effects of Intra-articular Injection of Agmatine and Clonidine into the Knee Joint Cavity on the Induction and Maintenance of Arthritic Pain in Rats

Lee MJ, Shim HS, Seol GH, Kim PJ, Han SH, Yee J, Kim C, Lee KC, Kim HY, Min SS

BACKGROUND: Previous studies suggest that systemic administration of agmatine, endogenous ligand for imidazoline receptors has anti-hypernociceptive effects in experimental animal. However the peripheral effects of agmatine on inflammatory pain have...
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Phorbol 12-Myristate 13-Acetate Enhances Long-Term Potentiation in the Hippocampus through Activation of Protein Kinase Cdelta and epsilon

Kim EC, Lee MJ, Shin SY, Seol GH, Han SH, Yee J, Kim C, Min SS

Many intracellular proteins and signaling cascades contribute to the sensitivity of N-methyl-D-aspartate receptors (NMDARs). One such putative contributor is the serine/threonine kinase, protein kinase C (PKC). Activation of PKC by...
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