- Cytochrome P450 and Cancer
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Hong YS
- KMID: 2171140
- Ewha Med J.
- 2004 Mar;27(1):41-51.
- doi: 10.12771/emj.2004.27.1.41
The cytochrome P450(P450) are a large group of constitutive and inducible heme-containing enzymes, which have a central role in the oxidative metabolism of a diverse range of xenobiotics. The majority... -
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- Molecular aspects of organic ion transporters in the kidney
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Cha SH, Hitoshi E
- KMID: 2285231
- Korean J Physiol Pharmacol.
- 2001 Apr;5(2):107-122.
A function of the kidney is elimination of a variety of xenobiotics ingested and wasted endogenous compounds from the body. Organic anion and cation transport systems play important roles to protect the... -
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- Loss of Integrity: Impairment of the Blood-brain Barrier in Heavy Metal-associated Ischemic Stroke
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Kim JH, Byun HM, Chung EC, Chung HY, Bae ON
- KMID: 2317830
- Toxicol Res.
- 2013 Sep;29(3):157-164.
Although stroke is one of the leading causes of death and disability worldwide, preventive or therapeutic options are still limited. Therefore, a better understanding of the pathophysiological characteristics of this... -
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- Environmental Factors and Bioremediation of Xenobiotics Using White Rot Fungi
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Magan N, Fragoeiro , Bastos C
- KMID: 2312587
- Mycobiology.
- 2010 Dec;38(4):238-248.
This review provides background information on the importance of bioremediation approaches. It describes the roles of fungi, specifically white rot fungi, and their extracellular enzymes, laccases, ligninases, and peroxidises, in... -
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- Increased UDP-Glucuronosyltransferase Activity in the Liver Butylated Hydroxyanisole and Butylated Hydroxytoluence-Treated Rats
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Hong YS
- KMID: 2170841
- Ewha Med J.
- 1990 Dec;13(4):285-291.
- doi: 10.12771/emj.1990.13.4.285
Butylated hydroxyanisole(BHA) has been shown to decrease the toxicological and carcinogenic potential of a variety of chemicals. One possible mechanism for chemoprotection is that BHA increases intestinal UDP-glucronosyltransferase activity and... -
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- Microbiome-Linked Crosstalk in the Gastrointestinal Exposome towards Host Health and Disease
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Moon Y
- KMID: 2364762
- Pediatr Gastroenterol Hepatol Nutr.
- 2016 Dec;19(4):221-228.
- doi: 10.5223/pghn.2016.19.4.221
The gastrointestinal exposome represents the integration of all xenobiotic components and host-derived endogenous components affecting the host health, disease progression and ultimately clinical outcomes during the lifespan. The human gut... -
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- Head and Neck Squamous Cell Carcinoma: Genetic Polymorphisms and Occurrence Risks
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Tae K
- KMID: 2168264
- Hanyang Med Rev.
- 2013 Aug;33(3):170-177.
- doi: 10.7599/hmr.2013.33.3.170
Head and neck squamous cell carcinoma (HNSCC), which is the 5th most common cancer worldwide, is believed to be induced by environmental carcinogens and host genetic factors. The main etiologic... -
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- Platelet Shape Changes and Cytoskeleton Dynamics as Novel Therapeutic Targets for Anti-Thrombotic Drugs
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Shin EK, Park H, Noh JY, Lim KM, Chung JH
- KMID: 2378799
- Biomol Ther.
- 2017 May;25(3):223-230.
- doi: 10.4062/biomolther.2016.138
Platelets play an essential role in hemostasis through aggregation and adhesion to vascular injury sites but their unnecessary activation can often lead to thrombotic diseases. Upon exposure to physical or... -
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- The Change of Glutathione Metabolism in Liver and Kidney of Cisplatin treated Rats
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Kim SY, Chung JY, Kim JR, Kim JH
- KMID: 2352241
- Yeungnam Univ J Med.
- 1994 Dec;11(2):262-269.
- doi: 10.12701/yujm.1994.11.2.262
Glutathione (GSH) is a well-known antioxidative cellular component which is ubiquitous in nature. Several enzymes involved in GSH metabolism and recycling have been found to play important roles in detoxification... -
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- Introduction of Organic Anion Transporters (SLC22A) and a Regulatory Mechanism by Caveolins
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Lee WK, Jung SM, Kwak JO, Cha SH
- KMID: 2052264
- Electrolyte Blood Press.
- 2006 Mar;4(1):8-17.
- doi: 10.5049/EBP.2006.4.1.8
The kidney is an important organ for controlling the volume of body fluids, electrolytic balance and excretion/reabsorption of endogenous and exogenous compounds. Among these renal functions, excretion/reabsorption of endogenous and... -
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- Effect of Nifedipine on Induction of Cytochrome P-450 1A1 and 2B1 in Spontaneously Hypertensive Rate
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Hong YS, Kim HL, Park HY, Pae YS, Park SS
- KMID: 1964943
- Ewha Med J.
- 1995 Sep;18(3):161-167.
- doi: 10.12771/emj.1995.18.3.161
Cytochrome P-450(CYP) enzymes are important in catalyzing the hiotransffrmation on manyendogeneous compounds and xenobiotics, including drugs and carcinogens. In the presentstudy, effect of nifedipine a voltage dependent calcium channel blocker... -
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- Effects of AMP-activated Protein Kinase Activating Compounds and Its Mechanism
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Choi HC
- KMID: 2049802
- Yeungnam Univ J Med.
- 2012 Dec;29(2):77-82.
- doi: 10.12701/yujm.2012.29.2.77
AMP-activated protein kinase (AMPK) is an important cellular fuel sensor. Its activation requires phosphorylation at Thr-172, which resides in the activation loop of the alpha1 and alpha2 subunits. Several AMPK... -
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- Recent Advances for Enhancing Drug Metabolizing Functions of Hepatocyte-like Cells Derived from Human Pluripotent Stem Cells
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Han J, Kim JH
- KMID: 2129472
- Hanyang Med Rev.
- 2015 Nov;35(4):196-206.
- doi: 10.7599/hmr.2015.35.4.196
Hepatocyte-like cells (HLCs) derived from human pluripotent stem cells are a promising cell source for drug screening and toxicity tests. Thus, various hepatic differentiating protocols have been developed, leading to... -
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- Genetic Polymorphism of Xenobiotics Metabolizing Enzymes and Individual Susceptible Genes to Colorectal Cancer Patients in Korea
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Lee HW, Kim MS, Jung PJ, Kim HJ, Kong G, Chun H
- KMID: 2025764
- J Korean Soc Coloproctol.
- 2002 Aug;18(4):205-215.
Individual susceptibility to cancers may result from several factors including differences in xenobiotics metabolism, DNA repair, altered oncogenes and suppressor genes, and environmental carcinogen exposures. To determine the frequencies of... -
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- AMP-activated protein kinase Activating Agent and Its Implication
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Choi HC
- KMID: 1497647
- Endocrinol Metab.
- 2012 Jun;27(2):109-115.
- doi: 10.3803/EnM.2012.27.2.109
AMP-activated protein kinase (AMPK) is an important cellular fuel sensor. Activation of AMPK requires phosphorylation at threonine (Thr)-172, which resides in the activation loop of the alpha1 and alpha2 subunits.... -
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- Cytochrome P450 2E1 activity in a Korean population
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Muhn DH, Chae JM, Bahn JY, Song HJ, Kim HK, Kwon JT, Sohn DR
- KMID: 1554771
- Korean J Physiol Pharmacol.
- 1997 Oct;1(5):597-602.
Cytochrome P450 2E1 (CYP2E1) is involved in the toxicity and carcinogenicity of a number of solvents and xenobiotics. Like the various types of oxidation pharmacogenetics, the activity of the enzyme shows a discernible... -
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- Association of NQO1 Polymorphism with Multiple Myeloma Risk in Koreans
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Kang SH, Kim TY, Kim HY, Lee YK, Moon HW, Lee DS, Cho HI
- KMID: 2238893
- Korean J Lab Med.
- 2006 Apr;26(2):71-76.
- doi: 10.3343/kjlm.2006.26.2.71
BACKGROUND: NAD(P)H:quinone oxidoreductase 1 (NQO1) is an important enzyme in the metabolism of xenobiotics. NQO1 609C -> T (NQO1*2) has been reported to be associated with reduced enzyme activity, benzene-induced... -
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- Occurrence and Specific Type of p53 and H-ras Mutations Based on Polymorphisms of NAT2 and GSTM1 in Human Bladder Cancer
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Kim WJ, Lee SC, Woo SH, Kim H
- KMID: 2060817
- Korean J Urol.
- 1999 Jul;40(7):869-877.
PURPOSE: Cancer development depends on not only activation of oncogene or inactivation of tumor suppressor gene but also activities of enzymes involved in the metabolism of various carcinogenic xenobiotics, such... -
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- Immunohistochemical study of glutathione S-transferase in preneoplastic and neoplastic lesions of human urinary bladder
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Moon WC, Kim IK, Kim YS, Park YW, Song KY
- KMID: 1913154
- Korean J Urol.
- 1993 Jun;34(3):391-401.
Glutathione S-transferase(GST) is a family of enzymes which plays an important role in cellular detoxification by catalyzing the conjugation of electrophilic xenobiotics with glutathione and recently have been shown to... -
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- Tanshinone IIA Protects Endothelial Cells from Hâ‚‚Oâ‚‚-Induced Injuries via PXR Activation
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Zhu H, Chen Z, Ma Z, Tan H, Xiao C, Tang X, Zhang B, Wang Y, Gao Y
- KMID: 2395809
- Biomol Ther.
- 2017 Nov;25(6):599-608.
- doi: 10.4062/biomolther.2016.179
Tanshinone IIA (Tan IIA) is a pharmacologically active substance extracted from the rhizome of Salvia miltiorrhiza Bunge (also known as the Chinese herb Danshen), and is widely used to treat... -
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