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Gintonin, an exogenous ginseng-derived LPA receptor ligand, promotes corneal wound healing

Kim HJ, Kim JY, Lee BH, Choi SH, Rhim H, Kim HC, Ahn SY, Jeong SW, Jang M, Cho IH, Nah SY

Ginseng gintonin is an exogenous ligand of lysophosphatidic acid (LPA) receptors. Accumulating evidence shows LPA helps in rapid recovery of corneal damage. The aim of this study was to evaluate...
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Therapeutic effect of topical application of curcumin during treatment of radiation burns in a mini-pig model

Kim J, Park S, Jeon BS, Jang WS, Lee SJ, Son Y, Rhim KJ, Lee SI, Lee SS

Curcumin protects the skin against radiation-induced epidermal damage and prevents morphological changes induced by irradiation skin, thereby maintaining the epidermal thickness and cell density of basal layers. In this study,...
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Effects of Polydeoxyribonucleotide in the Treatment of Pressure Ulcers

Kim JY, Pak CS, Park JH, Jeong JH, Heo CY

This study aimed to examine the positive effects of polydeoxyribonucleotide (PDRN) on the wound-healing process in pressure ulcers. In this randomized controlled trial, the effects of PDRN were compared over...
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Epithelial Wound Healing after Cataract Surgery Comparing Two Different Topical Fluoroquinolones

Han KE, Chung WS, Kim TI, Kim S, Kim T, Kim EK

PURPOSE: To compare the epithelial wound healing response of two preservative-free fluoroquinolones, moxifloxacin and levofloxacin, in patients who underwent cataract surgery. MATERIALS AND METHODS: In this prospective, evaluator-masked, randomized clinical trial,...
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Effect of Recombinant Human Epidermal Growth Factor Against Cutaneous Scar Formation in Murine Full-thickness Wound Healing

Kim YS, Lew DH, Tark KC, Rah DK, Hong JP

A visible cutaneous scar develops from the excess formation of immature collagen in response to an inflammatory reaction. This study examined the role of epidermal growth factor (EGF) in the...
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Comparison of the Efficacies of Silver-Containing Dressing Materials for Treating a Full-Thickness Rodent Wound Infected by Methicillin-resistant Staphylococcus aureus

Lee JH, Chae JD, Kim DG, Hong SH, Lee WM, Ki M

BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) may cause infections during wound dressing. We aimed to compare the antibacterial activities and wound-healing effects of commercially available silver-coated or silver-impregnated wound dressings on...
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Therapeutic Effects of Topical Application of Ozone on Acute Cutaneous Wound Healing

Kim HS, Noh SU, Han YW, Kim KM, Kang H, Kim HO, Park YM

This study was undertaken to evaluate the therapeutic effects of topical ozonated olive oil on acute cutaneous wound healing in a guinea pig model and also to elucidate its therapeutic...
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Recombinant tetra-cell adhesion motifs supports adhesion, migration and proliferation of keratinocytes/fibroblasts, and promotes wound healing

Jung MY, Thapa N, Kim JE, Yang JD, Cho BC, Kim IS

  • KMID: 1090969
  • Exp Mol Med.
  • 2007 Oct;39(5):663-672.
An extracellular matrix protein plays an important role in skin wound healing. In the present study, we engineered a recombinant protein encompassing the 9th and 10th type III domains of...
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Topical application of epidermal growth factor accelerates wound healing by myofibroblast proliferation and collagen synthesis in rat

Kwon YB, Kim HW, Roh DH, Yoon SY, Baek RM, Kim JY, Kweon HY, Lee KG, Park YH, Lee JH

Recombinant human epidermal growth factor (rhEGF) stimulates the proliferation and migration of epithelial cells in human cell culture systems and animal models of partial-thickness skin wounds. This study investigated the effect of a topical...
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Polysaccharides isolated from Phellinus gilvus enhances dermal wound healing in streptozotocin-induced diabetic rats

Bae JS, Jang KH, Jin HK

  • KMID: 1114859
  • J Vet Sci.
  • 2005 Jun;6(2):161-164.
Dermal wound healing is a complex process that involved inflammation leading to re-epithelialization, granulation tissue, and tissue remodeling. Previous studies from our laboratory have shown that polysaccharides isolated from fungus,...
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Paradoxical effects of elastase inhibitor guamerin on the tissue repair of two different wound models: sealed cut and exposed tongue wounds

Lee SK, Lee SS, Song IS, Kim YS, Park YW, Joo JY, Um HS, Kim JW, Kim KY, Choi SJ, Jung KH, Chung SI

  • KMID: 1097108
  • Exp Mol Med.
  • 2004 Jun;36(3):259-267.
Innate elastase inhibitors are known to be putatively involved in the regulation of tissue inflammation by inhibiting polymorphonuclear leukocyte (PMN) derived proteinases. The aim of this study was to evaluate...
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Effect of topically applied Na-hyaluronan on experimental corneal alkali wound healing

Chung JH, Kim HJ, Fagerholmb P, Cho BC

The effect of topically applied 1% sodium hyaluronate (Na-HA) on the healing of a standardized corneal alkali wound was studied. The healing of the epithelium, stroma, and endothelium was evaluated...
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Homologous fibronectin enhances healing of excised wounds in rats

Jo JS, Hong SB, Shin HI, Choi JJ

In order to evaluate the effects of a topical application of homologous fibronectin on the healing of skin wounds, we made 2 excisional wounds on the back skin of each...
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Effects of tissue adhesive (Tisseel(R)) on corneal wound healing in lamellar keratoplasty in rabbits

Kim MS, Kim JH

The purpose of this study was to compare corneal wound healing between suture and sutureless lamellar keratoplasty in the rabbit eye. The tissue adhesive (Tisseel, Vienna) a commercially available two...
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