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Vascularization Methods for Tissue Engineers

Kim MJ, Chi BH, Cho MJ, Whang YM, Chang IH

Tissue engineering is limited by our inability to adequately vascularize tissues post implantation because all tissue-engineered substitutes (with the exception of cornea and cartilage) require a vascular network to provide...
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Evoked Potentials in Wilson Disease

Sunwoo IN, Whang YM, Kim KW, Cho PZ

  • KMID: 1661989
  • J Korean Neurol Assoc.
  • 1986 Dec;4(2):195-199.
Evoked potential studies including BAEP (Brainstem Auditory Evoked Potential), VEP (Visual Evoked Potential) and SEP (Somatosensory Evoked Potential-median nerve stimulated at wrist) were performed in 6 patients of wilson disease....
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Manipulating the Angiogenesis by Inflammation

Kim MJ, Jin S, Whang YM, Chang IH

There exists a need to develop strategies that promote neovascularization in virtually all tissue engineering and regenerative medicine efforts. While research typically focuses on understanding and exploiting the role of...
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Recombinant Bacille Calmette–Guérin for Immunotherapy in Nonmuscle Invasive Bladder Cancer

Jin S, Whang YM, Chang IH

Intravesical instillation of Mycobacterium bovis bacille Calmette–Guérin (BCG) has been used for treating nonmuscle invasive bladder cancer as the forefront of immunotherapy, but BCG is ineffective in approximately 30–40% of...
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Application of Bioprinting to Cancer Research

Cho MJ, Chi BH, Kim MJ, Whang YM, Chang IH

Three-dimensional (3D) printing is an additive manufacturing process by which precursor materials are deposited layer by layer to form complex 3D geometries from computer-aided designs, and bioprinting offers the ability...
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The Present and Future of the Cancer Microenvironment Bioprinting

Cho MJ, Chi BH, Kim MJ, Whang YM, Chang IH

Cancer is the tissue complex consisted with heterogeneous cellular compositions, and microenvironmental cues. During the various stages of cancer initiation, development, and metastasis, cell–cell interactions as well as cell-extracellular matrix...
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Genetically Modified Bacteria as Targeted Agent for Cancer

Jin S, Whang YM, Chang IH

With the emergence of microbiome as a major player in many human diseases, bacteria as therapeutics are gaining significant interest. Whole bacteria or cytotoxic or immunogenic peptides carried by them...
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AKAP12alpha is Associated with Promoter Methylation in Lung Cancer

Jo U, Whang YM, Kim HK, Kim YH

  • KMID: 2166059
  • Cancer Res Treat.
  • 2006 Jun;38(3):144-151.
PURPOSE: Promoter methylation is an important mechanism for silencing tumor-suppressor genes in cancer and it is a promising tool for the development of molecular biomarkers. The purpose of the present...
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Comparison of Sensitivity and Specificity of the Polymerase Chain Reaction for the M. tuberculois in CSF of Patients,Diagnosed as Tuberculous Meningitis and of Controls

Kim KK, Kim JS, Whang YM, Lee MC, Song IS, Kim IS

  • KMID: 1686771
  • J Korean Neurol Assoc.
  • 1993 Sep;11(3):392-403.
The diagnostic value of the DNA polymerase chain reaction for the detection of M. tuberculosis in tuberculous meningitis uas established by using cerebrospinal fluids obtained from 7 bacteriologically confirmed patients...
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Bacillus Calmette-Guérin (BCG)-Cell Wall Skeleton as Immunotherapeutic Option for BCG-Refractory Superficial Bladder Cancer

Whang YM, Yoon DH, Hwang GY, Choi YW, Chang IH

Although intravesical instillation of Mycobacterium bovis bacillus Calmette-Guérin (BCG) is the most successful cancer immunotherapy for superficial bladder cancer, the serious side effects are frequently arisen by using live mycobacteria....
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No Association between Promoter Polymorphism of STK11 Gene and Lung Cancer Risk in the Korean Population

Sung JS, Whang YM, Park KH, Ryu JS, Choi JG, Seo JH, Shin SW, Kim JS, Kim YH

  • KMID: 1972674
  • Cancer Res Treat.
  • 2009 Dec;41(4):211-217.
PURPOSE: Serine-threonine kinase11 (STK11) was originally identified in 1997 as the causative mutation that's responsible for Peutz-Jeghers Syndrome (PJS). Several recent studies have reported that the STK11 gene is an...
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RASSF1A Suppresses Cell Migration through Inactivation of HDAC6 and Increase of Acetylated alpha-Tubulin

Jung HY, Jung JS, Whang YM, Kim YH

  • KMID: 2167619
  • Cancer Res Treat.
  • 2013 Jun;45(2):134-144.
PURPOSE: The RAS association domain family protein 1 (RASSF1) has been implicated in a tumor-suppressive function through the induction of acetylated alpha-tubulin and modulation of cell migration. However, the mechanisms...
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Combinational Treatment with Retinoic Acid Derivatives in Non-small Cell Lung Carcinoma In Vitro

Choi EJ, Whang YM, Kim SJ, Kim HJ, Kim YH

The growth inhibitory effects of four retinoic acid (RA) derivatives, 9-cis RA, 13-cis RA, N-(4-hydroxyphenyl) retinamide (4-HPR), and all-trans retinoic acid (ATRA) were compared. In addition, the effects of various...
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Identification of Downstream Genes of the mTOR Pathway that Predict Recurrence and Progression in Non-Muscle Invasive High-Grade Urothelial Carcinoma of the Bladder

Jin S, Chang IH, Kim JW, Whang YM, Kim HJ, Hong SA, Lee TJ

Microarray analysis was used to investigate the lack of identified mammalian target of rapamycin (mTOR) pathway downstream genes to overcome cross-talk at non-muscle invasive high-grade (HG)-urothelial carcinoma (UC) of the...
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NBR1 and KIF14 Downstream of the Mammarian Target of Rapamycin Pathway Predict Recurrence in Nonmuscle Invasive Low Grade Urothelial Carcinoma of the Bladder

Lee DG, Kim HJ, Jin S, Kim JW, Whang YM, Lee TJ, Chang IH

PURPOSE: The lack of identified mammalian target of rapamycin (mTOR) pathway downstream genes that overcome cross-talk in nonmuscle invasive low grade (LG)-urothelial carcinoma (UC) of the bladder is a clinical...
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Retinoic Acid Enhances Drug-Induced Cell Death in Anticancer Drug-Resistant Cell Lines

Whang YM, Kim YH, Shin SW, Kim BS, Kim JS, Yoo YD, Park SH

  • KMID: 2134356
  • Cancer Res Treat.
  • 2002 Jun;34(3):212-217.
PURPOSE: Retinoids (RA), a group of vitamin A derivatives, is known to be important for regulation of normal cellular growth and differentiation. RA treatment of various cancers resulted in cell...
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Poloxamer 407 Hydrogels for Intravesical Instillation to Mouse Bladder: Gel-Forming Capacity and Retention Performance

Kim SH, Kim SR, Yoon HY, Chang IH, Whang YM, Cho MJ, Kim MJ, Kim SY, Lee SJ, Choi YW

PURPOSE: Poloxamer 407 (P407) thermo-sensitive hydrogel formulations were developed to enhance the retention time in the urinary bladder after intravesical instillation. MATERIALS AND METHODS: P407 hydrogels (P407Gels) containing 0.2 w/w% fluorescein...
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