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Uracil-DNA glycosylase-treated reverse transcription loop-mediated isothermal amplification for rapid detection of avian influenza virus preventing carry-over contamination

Kim EM, Jeon HS, Kim JJ, Shin YK, Lee YJ, Yeo SG, Park CK

Here, we describe a uracil-DNA glycosylase (UNG)-treated reverse transcription loop-mediated isothermal amplification (uRT-LAMP) for the visual detection of all subtypes of avian influenza A virus (AIV). The uRT-LAMP assay can...
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Volume-reserving Surgery after Photodynamic Therapy for Biliary Papillomatosis: A Case Report

Cheong CO, Lim JH, Park JS, Park SW, Kim HK, Kim KS

Biliary papillomatosis is rare, and its pathogenic mechanisms are not yet clear. Because of its high risk for malignancy transformation, surgical resection is regarded as a standard treatment. Photodynamic therapy...
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High-dose oral tegafur-uracil maintenance therapy in patients with uterine cervical cancer

Sakaguchi , Motohara T, Saito F, Takaishi K, Fukumatsu , Tohya T, Shibata S, Mimori H, Tashiro H, Katabuchi

OBJECTIVE: The aim of this study was to determine the efficacy and toxicity of oral administration of tegafur-uracil (UFT) at a high dose, 600 mg/day, based on the tegafur dose,...
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Comparison of DPP-4 Inhibitors

Kim NH, Kim SG

During past several years, a novel class of antihyperglycemic agents, dipeptidyl peptidase-4 (DPP-4) inhibitors, has become one of the most important options in the management of type 2 diabetes. These...
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Clinical predictive factors of pathologic tumor response after preoperative chemoradiotherapy in rectal cancer

Choi CH, Kim WD, Lee SJ, Park WY

  • KMID: 2316706
  • Radiat Oncol J.
  • 2012 Sep;30(3):99-107.
PURPOSE: The aim of this study was to identify clinical predictive factors for tumor response after preoperative chemoradiotherapy (CRT) in rectal cancer. MATERIALS AND METHODS: The study involved 51 patients who...
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Discoid Lupus Erythematosus-like Eruption Induced by Tegafur - Uracil (UFT)

Yoon J, Seo SH, Kye YC, Ahn HH

  • KMID: 2301813
  • Korean J Dermatol.
  • 2010 Nov;48(11):1004-1007.
The second-generation oral anticancer agent UFT is a combination of uracil, which has fluorouracil's (5-FU) degradation-inhibitory effect, and tegafur, which is slowly converted to 5-FU in vivo, and UFT shows...
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A Case of Fixed Drug Eruption Induced by Tegafur-Uracil(TEGASIL)

Heo YS, Song HJ, Oh CH

  • KMID: 2247720
  • Korean J Dermatol.
  • 2010 Feb;48(2):155-157.
A mixture of tegafur and uracil (TEGASIL) is a common antineoplastic agent. Tegafur is a fluoropyrimidine structurally similar to 5-fluorouracil (5-FU); uracil slows the degradation of 5-FU by dihydropyrimidine dehydrogenase,...
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Chemical Constituents of the Fruiting Bodies of Clitocybe nebularis and Their Antifungal Activity

Kim YS, Lee IK, Seok SJ, Yun BS

  • KMID: 2411406
  • Mycobiology.
  • 2008 Jun;36(2):110-113.
During a continuing search for antimicrobial substances from Korean native wild mushroom extracts, we found that the methanolic extract of the fruiting body of Clitocybe nebularis exhibited mild antifungal activity...
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Small Animal PET Imaging with [124I]FIAU for Herpes Simplex Virus Type 1 Thymidine Kinase Gene Expression in a Hepatoma Model

Chae MJ, Lee TS, Kim JY, Woo GS, Jumg WS, Chun KS, Kim JH, Lee JS, Ryu JS, Cheon GJ, Choi CW, Lim SM

  • KMID: 2313046
  • Nucl Med Mol Imaging.
  • 2008 Jun;42(3):235-234.
PURPOSE: The HSV1-tk gene has been extensively studied as a type of reporter gene. In hepatocellular carcinoma (HCC), only a small proportion of patients are eligible for surgical resection and...
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Bioavailability of the amino acid-attached prodrug as a new anti-HIV agent in rats

Chae KA, Cho HJ, Sung JM, Lee H, Seo DC, Kim JS, Shin HC

The primary objective of this study was to compare thepharmacokinetics of a new anti-human immunodeficiencyvirus agent 1-(2-amino-pyridin-4-ylmethyl)-6-(3,5-dimethyl-benzoyl)-5-isopropyl-1H-pyrimidine-2,4-dione (VP-0502)with its amino acid prodrug alanine amide of VP-0502(VP-0502AL), following intravenous and oral...
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DNA methylation of Bcl-2 family genes in cancer cells

Kang Y, Lee SY, Jung SG, Han J, Ko JJ, Bae J, Na YJ, Lee C, Mock JU, Kim SJ, Hwang YY

  • KMID: 2273147
  • Korean J Obstet Gynecol.
  • 2007 Jul;50(7):997-1002.
OBJECTIVE: Promoter methylation of Bcl-2 family genes in cancer cells were studied to verify possible correlation between DNA methylation pattern of Bcl-2 family members and cancer. METHODS: The genomic DNAs...
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A Case of 5-fluorouracil-induced Phototoxicity

Cho EA, Kim SY

  • KMID: 2087201
  • Korean J Dermatol.
  • 2006 Nov;44(11):1364-1366.
5-fluorouracil (5-FU) is an antimetabolite which prevents thymine synthesis and suppresses the utilization of preformed uracil. A variety of cutaneous reactions have been reported with the use of systemic 5-FU,...
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Postoperative Adjuvant Chemoradiotherapy in Rectal Cancer

Chang SK, Kim JW, Oh D, Chong SY, Shin HS

  • KMID: 1512291
  • J Korean Soc Ther Radiol Oncol.
  • 2006 Sep;24(3):157-163.
PURPOSE: To evaluate the role of postoperative adjuvant chemoradiotherapy in rectal cancer, we retrospectively analyzed the treatment outcome of patients with rectal cancer taken curative surgical resection and postoperative adjuvant...
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Lesch-Nyhan syndrome and purine and pyrimidine metabolism didorders

Kim SZ

  • KMID: 2168076
  • Hanyang Med Rev.
  • 2005 Aug;25(3):92-101.
Purine & pyrimidine nucleotides are basic constituents of cellular DNA and RNA polynucleotides. Their function includes regulation of cell metabolism and function, energy conservation and transport and formation of coenzymes...
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Methylenetetrahydrofolate Reductase C677T and A1298C Polymorphisms in Colorectal Cancer

Park WC, Lee JK

  • KMID: 1606360
  • J Korean Soc Coloproctol.
  • 2005 Aug;21(4):241-246.
PURPOSE: Recently, the role of vitamins, folate in particular, has been emphasized in the maintenance of health. Folate deficiency is known to give rise to developmental delay, pre-mature vascular disease,...
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Methylenetetrahydrofolate Reductase C677T Polymorphism in Gastric Cancer

Seo W, Park WC, Lee JK, Kim JJ

  • KMID: 2372764
  • J Korean Gastric Cancer Assoc.
  • 2005 Mar;5(1):10-15.
PURPOSE: Recently the role of vitamins, folate in particular, has been emphasized in the maintenance of health. Folate deficiency is known to give rise to developmental delay, immature vascular disease,...
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Oxaliplatin and UFT, leucovorin combination chemotherapy in patients with advanced colorectal cancer

Shin JH, Kim SY, Woo CM, Kim YS, Kim JY, Seo JH, Lee WS, Bae SH, Ryoo HM, Lee HI, Shin IH, Kim MK, Lee JL, Lee KH, Hyun MS

  • KMID: 2252594
  • Korean J Med.
  • 2004 Jul;67(1):58-64.
BACKGROUND: UFT/oral leucovorin (LV) provided a safer, more convenient oral alternative to bolus i.v. 5-Fluorouracil/LV regimen for advanced colorectal cancer while producing equivalent survival. We evaluated the efficacy and safety...
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Oral Tegafur-uracil Plus Folinic Acid versus Intravenous 5-fluorouracil Plus Folinic Acid as Adjuvant Chemotherapy of Colon Cancer

Kim DJ, Kim TI, Suh JH, Cho YS, Shin SK, Kang JK, Kim NK, Kim WH

To compare, in terms of compliance, toxicity, quality of life (QOL) and efficacy, intravenous 5-fluorouracil plus folinic acid with oral tegafur-uracil plus folinic acid as postoperative adjuvant chemotherapy after curative...
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Clinical Pharmacokinetics of Tegafur Administered with Epirubicin and Cisplatin in Patients with Advanced Gastric Cancer

Kang JH, Kim YL, Cho HK, Lee ES, Cha SJ, Hong YS, Lee KS, Kuh HJ

  • KMID: 2166181
  • Cancer Res Treat.
  • 2003 Jun;35(3):224-231.
PURPOSE: Tegafur, an oral prodrug of 5-fluorouracil (5-FU), has been used in the treatment of gastric cancers. UFT (tegafur + uracil) has been developed to enhance the efficacy of tegafur....
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The Efficient Transformation of Pleurotus ostreatus using REMI Method

Joh JH, Kim BG, Chu KS, Kong WS, Yoo YB, Lee CS

Restriction enzyme-mediated integration (REMI) was used to transform uracil auxotrophs of Pleurotus ostreatus to prototrophy. When protoplasts of Pleurotus ostreatus were treated by the reaction mixture containing 10 units of...
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