Korean J Dermatol.
2006 Nov;44(11):1364-1366.
A Case of 5-fluorouracil-induced Phototoxicity
- Affiliations
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- 1Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Korea. dervint@catholic.ac.kr
Abstract
- 5-fluorouracil (5-FU) is an antimetabolite which prevents thymine synthesis and suppresses the utilization of preformed uracil. A variety of cutaneous reactions have been reported with the use of systemic 5-FU, the most common being photosensitivity. We report a case of 5-FU induced phototoxicity in a 73-year-old male. The patient had tender and slightly pruritic scaly and crusted erythema on sun-exposed areas. A biopsy revealed necrotic keratinocytes with epidermal degeneration. After the cessation of 5-FU, the skin lesions showed a marked improvement, and there was no further photosensitivity to the skin.
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