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Betulinic acid prevents alcohol-induced liver damage by improving the antioxidant system in mice

Yi J, Xia W, Wu J, Yuan L, Wu J, Tu D, Fang J, Tan Z

Betulinic acid (BA), a pentacyclic lupane-type triterpene, has a wide range of bioactivities. The main objective of this work was to evaluate the hepatoprotective activity of BA and the potential...
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Immunomodulatory effects of betulinic acid from the bark of white birch on mice

Yi JE, Obminska-Mrukowicz B, Yuan LY, Yuan H

The objective of this study was to explore the immunomodulatory effects of betulinic acid (BA) extracted from the bark of white birch on mice. Female mice were orally administered BA...
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Celastrol inhibits production of nitric oxideandproinflammatory cytokines through MAPK signal transduction and NF-kappaB in LPS-stimulated BV-2 microglial cells

Jung HW, Chung YS, Kim YS, Park YK

  • KMID: 1091066
  • Exp Mol Med.
  • 2007 Dec;39(6):715-721.
Excessive production of nitric oxide (NO) and proinflammatory cytokines from activated microglia play an important role in human neurodegenerative disorders. Here, we investigated whether celastrol, which has been used as...
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