- Role of MicroRNA-34a in Anti-Apoptotic Effects of Granulocyte-Colony Stimulating Factor in Diabetic Cardiomyopathy
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Park IH, Song YS, Joo HW, Shen GY, Seong JH, Shin NK, Cho YJ, Lee Y, Shin JH, Lim YH, Kim H, Kim KS
- KMID: 2470965
- Diabetes Metab J.
- 2020 Feb;44(1):173-185.
- doi: 10.4093/dmj.2018.0211
BACKGROUND: Recent studies have shown that microRNAs (miRNAs) are involved in the process of cardiomyocyte apoptosis. We have previously reported that granulocyte-colony stimulating factor (G-CSF) ameliorated diastolic dysfunction and attenuated... -
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- MicroRNA-138 Suppresses Adipogenic Differentiation in Human Adipose Tissue-Derived Mesenchymal Stem Cells by Targeting Lipoprotein Lipase
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Wang Y, Lin L, Huang Y, Sun J, Wang X, Wang P
- KMID: 2463798
- Yonsei Med J.
- 2019 Dec;60(12):1187-1194.
- doi: 10.3349/ymj.2019.60.12.1187
PURPOSE: Adipogenic differentiation of adipose tissue-derived mesenchymal stem cells (AMSCs) is critical to many disease-related disorders, such as obesity and diabetes. Studies have demonstrated that miRNA-138 (miR-138) is closely involved... -
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- Isolation of Secretome with Enhanced Antifibrotic Properties from miR-214-Transfected Adipose-Derived Stem Cells
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Park JH, Kim OH, Kim KH, Hong HE, Seo H, Choi HJ, Ahn J, Lee TY, Kim SJ
- KMID: 2463682
- J Korean Med Sci.
- 2019 Nov;34(45):e273.
- doi: 10.3346/jkms.2019.34.e273
BACKGROUND: Secretome refers to the total set of molecules secreted or surface-shed by stem cells. The limitations of stem cell research have led numerous investigators to turn their attention to... -
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- 15-Deoxy-Δ(12,14)-prostaglandin J₂ Upregulates the Expression of 15-Hydroxyprostaglandin Dehydrogenase by Inducing AP-1 Activation and Heme Oxygenase-1 Expression in Human Colon Cancer Cells
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Park JM, Na HK
- KMID: 2468800
- J Cancer Prev.
- 2019 Sep;24(3):183-191.
- doi: 10.15430/JCP.2019.24.3.183
BACKGROUND: Abnormal upregulation of prostaglandin Eâ‚‚ (PGEâ‚‚) is considered to be a key oncogenic event in the development and progression of inflammation-associated human colon cancer. It has been reported that... -
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- Regulation of porcine endogenous retrovirus by dual LTR1+2 (Long Terminal Region) miRNA in primary porcine kidney cells
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Chung HC, Nguyen VG, Moon HJ, Park YH, Park BK
- KMID: 2464096
- J Vet Sci.
- 2019 Sep;20(5):e50.
- doi: 10.4142/jvs.2019.20.e50
Porcine endogenous retroviruses (PERVs) integrate into germline DNA as proviral genome that enables vertical transmission from parents to their offspring. The provirus usually survives as part of the host genome... -
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- Combined Detection of Serum MiR-221-3p and MiR-122-5p Expression in Diagnosis and Prognosis of Gastric Cancer
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Zhang Y, Huang H, Zhang Y, Liao N
- KMID: 2458831
- J Gastric Cancer.
- 2019 Sep;19(3):315-328.
- doi: 10.5230/jgc.2019.19.e28
PURPOSE: To investigate the clinical value of serum miR-221-3p and miR-122-5p expression levels in the diagnosis and prognosis of gastric cancer. MATERIALS AND METHODS: Serum samples from 141 gastric cancer cases... -
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- Radioactive Iodine-Refractory Differentiated Thyroid Cancer and Redifferentiation Therapy
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Liu J, Liu Y, Lin Y, Liang J
- KMID: 2458623
- Endocrinol Metab.
- 2019 Sep;34(3):215-225.
- doi: 10.3803/EnM.2019.34.3.215
The retained functionality of the sodium iodide symporter (NIS) expressed in differentiated thyroid cancer (DTC) cells allows the further utilization of post-surgical radioactive iodine (RAI) therapy, which is an effective... -
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- Suppression of CD81 promotes bladder cancer cell invasion through increased matrix metalloproteinase expression via extracellular signal-regulated kinase phosphorylation
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Park HS, Lee S, Lee J, Shin HB, Yoo SM, Lee MS, Park J
- KMID: 2455968
- Investig Clin Urol.
- 2019 Sep;60(5):396-404.
- doi: 10.4111/icu.2019.60.5.396
PURPOSE: CD81 is a prognostic biomarker for high-grade bladder cancer (BC). In this study, we aimed to determine the functional mechanisms underlying the role of CD81 in BC progression. MATERIALS AND... -
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- Cell Death Mechanisms in Esophageal Squamous Cell Carcinoma Induced by Vesicular Stomatitis Virus Matrix Protein
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Douzandegan Y, Tahamtan A, Gray Z, Nikoo HR, Tabarraei , Moradi A
- KMID: 2456577
- Osong Public Health Res Perspect.
- 2019 Aug;10(4):246-252.
- doi: 10.24171/j.phrp.2019.10.4.08
OBJECTIVES: Vesicular stomatitis virus (VSV) is under development as an oncolytic virus due to its preferential replication in cancer cells and oncolytic activity, however the viral components responsible have not... -
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- Silencing of LncRNA-ANCR Promotes the Osteogenesis of Osteoblast Cells in Postmenopausal Osteoporosis via Targeting EZH2 and RUNX2
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Cai N, Li C, Wang F
- KMID: 2452956
- Yonsei Med J.
- 2019 Aug;60(8):751-759.
- doi: 10.3349/ymj.2019.60.8.751
PURPOSE: This study aimed to explore the effects and mechanisms of long non-coding RNA (lncRNA) anti-differentiation non-coding RNA (ANCR) on the osteogenesis of osteoblast cells in postmenopausal osteoporosis (PMOP). MATERIALS AND... -
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- FGF-17 from Hypoxic Human Wharton's Jelly-Derived Mesenchymal Stem Cells Is Responsible for Maintenance of Cell Proliferation at Late Passages
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Han KH, Kim MH, Jeong GJ, Kim AK, Chang JW, Kim DI
- KMID: 2465898
- Int J Stem Cells.
- 2019 Jul;12(2):279-290.
- doi: 10.15283/ijsc18042
BACKGROUND AND OBJECTIVES: Although it is well known that hypoxic culture conditions enhance proliferation of human mesenchymal stem cells, the exact mechanism is not fully understood. In this study, we... -
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- Jab1 Silencing Inhibits Proliferation and Sensitizes to Cisplatin in Biliary Tract Cancer
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Nam AR, Kim JW, Park JE, Bang JH, Jin MH, Oh DY, Bang YJ
- KMID: 2454281
- Cancer Res Treat.
- 2019 Jul;51(3):886-900.
- doi: 10.4143/crt.2018.375
PURPOSE: Jab1 is a coactivator of c-Jun that enhances the transcriptional function of c-Jun. Jab1 is frequently overexpressed in various cancers and is associatedwith poor prognosis of cancer patients. Thus,... -
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- Matrix Production in Chondrocytes Transfected with Sex Determining Region Y-Box 9 and Telomerase Reverse Transcriptase Genes: An In Vitro Evaluation from Monolayer Culture to Three-Dimensional Culture
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Noorhidayah MN, Zulkifly A, Khalid KA, Zainol I, Zamli Z, Sha'ban M
- KMID: 2449239
- Tissue Eng Regen Med.
- 2019 Jun;16(3):285-299.
- doi: 10.1007/s13770-019-00191-1
BACKGROUND: This study aimed to observe the cartilaginous matrix production in SRY (sex determining region Y)-box 9 (SOX9)- and/or telomerase reverse transcriptase (TERT)-transfected chondrocytes from monolayer to three-dimensional (3D) culture. METHODS:... -
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- miR-140-3p Knockdown Suppresses Cell Proliferation and Fibrogenesis in Hepatic Stellate Cells via PTEN-Mediated AKT/mTOR Signaling
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Wu SM, Li TH, Yun H, Ai HW, Zhang KH
- KMID: 2446962
- Yonsei Med J.
- 2019 Jun;60(6):561-569.
- doi: 10.3349/ymj.2019.60.6.561
PURPOSE: Liver fibrosis is a major cause of morbidity and mortality and the outcome of various chronic liver diseases. Activation of hepatic stellate cells (HSCs) is the key event in... -
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- β-Catenin expression is associated with cell invasiveness in pancreatic cancer
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Nan JN, Kim OR, Lee MA
- KMID: 2448354
- Korean J Intern Med.
- 2019 May;34(3):618-625.
- doi: 10.3904/kjim.2017.155
BACKGROUND/AIMS: This study was tried to determine the role of β-catenin in invasion in pancreatic cancer. METHODS: We analyzed cancer invasiveness according to β-catenin expression in pancreatic cancer cell line. We... -
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- Involvement of a Novel Organic Cation Transporter in Paeonol Transport Across the Blood-Brain Barrier
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Gyawali A, Krol S, Kang YS
- KMID: 2447856
- Biomol Ther.
- 2019 May;27(3):290-301.
- doi: 10.4062/biomolther.2019.007
Paeonol has neuroprotective function, which could be useful for improving central nervous system disorder. The purpose of this study was to characterize the functional mechanism involved in brain transport of... -
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- Endoplasmic Reticulum Stress Induces MUC5AC and MUC5B Expression in Human Nasal Airway Epithelial Cells
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Kim MH, Bae CH, Choi YS, Na HG, Song SY, Kim YD
- KMID: 2447427
- Clin Exp Otorhinolaryngol.
- 2019 May;12(2):181-189.
- doi: 10.21053/ceo.2018.00493
OBJECTIVES: Endoplasmic reticulum (ER) stress is known to be associated with inflammatory airway diseases, and three major transmembrane receptors: double-stranded RNA-activated protein kinase-like ER kinase, inositol requiring enzyme 1, and... -
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- Effects of TGF-β1 Overexpression on Biological Characteristics of Human Dental Pulp-derived Mesenchymal Stromal Cells
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Salkın H, Gönen ZB, Ergen E, Bahar D, Çetin M
- KMID: 2447235
- Int J Stem Cells.
- 2019 Mar;12(1):170-182.
- doi: 10.15283/ijsc18051
OBJECTIVE: The aim of our study was to investigate the effect of Transforming growth factor beta-1 (TGF-β1) gene therapy on the surface markers, multilineage differentiation, viability, apoptosis, cell cycle, DNA... -
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- Pokemon Inhibits Transforming Growth Factor β-Smad4-Related Cell Proliferation Arrest in Breast Cancer through Specificity Protein 1
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Chen L, Zhong J, Liu JH, Liao DF, Shen YY, Zhong XL, Xiao X, Ding WJ, Peng XD, Xiong W, Zu XY
- KMID: 2441848
- J Breast Cancer.
- 2019 Mar;22(1):15-28.
- doi: 10.4048/jbc.2019.22.e11
PURPOSE: Pokemon, also known as ZBTB7A, belongs to the POZ and Krüppel (POK) family of transcription repressors and is implicated in tumor progression as a key proto-oncogene. This present study... -
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- MicroRNA-206 Reduces Osteosarcoma Cell Malignancy In Vitro by Targeting the PAX3-MET Axis
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Zhan FB, Zhang XW, Feng SL, Cheng J, Zhang Y, Li B, Xie LZ, Deng QR
- KMID: 2431633
- Yonsei Med J.
- 2019 Feb;60(2):163-173.
- doi: 10.3349/ymj.2019.60.2.163
PURPOSE: This study was undertaken to explore how miR-206 represses osteosarcoma (OS) development. MATERIALS AND METHODS: Expression levels of miR-206, PAX3, and MET mRNA were explored in paired OS and adjacent... -
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