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Protease-Activated Receptors 2-Antagonist Suppresses Asthma by Inhibiting Reactive Oxygen Species-Thymic Stromal Lymphopoietin Inflammation and Epithelial Tight Junction Degradation

Kim HJ, Lee SH, Jeong S, Hong SJ

PURPOSE: Protease-activated receptor 2 (PAR2) reportedly triggers the immune response in allergic asthma. We aimed to investigate the mechanism on allergic inflammation mediated by PAR2. METHODS: Human lung epithelial cells (A549...
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German Cockroach Extract Induces Matrix Metalloproteinase-1 Expression, Leading to Tight Junction Disruption in Human Airway Epithelial Cells

Lee KE, Jee HM, Hong JY, Kim MN, Oh MS, Kim YS, Kim KW, Kim KE, Sohn MH

PURPOSE: Cockroach exposure is a pivotal cause of asthma. Tight junctions are intercellular structures required for maintenance of the barrier function of the airway epithelium, which is impaired in this...
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Impact of the Endothelial Tight Junction Protein Claudin-5 on Clinical Profiles of Patients With COPD

Kim BG, Lee PH, Lee SH, Baek AR, Park JS, Lee J, Park SW, Kim DJ, Park CS, Jang AS

PURPOSE: The tight junction protein claudin-5 (CLDN5) is critical to the control of endothelial cellular polarity and pericellular permeability. The role of CLDN5 in chronic obstructive pulmonary disease (COPD) remains...
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Comparison of Tight Junction Protein-Related Gene mRNA Expression Levels between Male and Female Gastroesophageal Reflux Disease Patients

Kim JJ, Kim N, Park JH, Kim YS, Lee SM, Lee DH, Jung HC

BACKGROUND/AIMS: Male predominance has been observed in the erosive reflux disease (ERD), but reverse finding in nonerosive reflux disease (NERD). This suggests sex-specific medicine approach is needed but its mechanism...
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Akkermansia muciniphila-derived extracellular vesicles influence gut permeability through the regulation of tight junctions

Chelakkot , Choi Y, Kim DK, Park HT, Ghim J, Kwon Y, Jeon J, Kim MS, Jee YK, Gho YS, Park HS, Kim YK, Ryu SH

The gut microbiota has an important role in the gut barrier, inflammation and metabolic functions. Studies have identified a close association between the intestinal barrier and metabolic diseases, including obesity...
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Additive Effects of Rebamipide Plus Proton Pump Inhibitors on the Expression of Tight Junction Proteins in a Rat Model of Gastro-Esophageal Reflux Disease

Gweon TG, Park JH, Kim BW, Choi YK, Kim JS, Park SM, Kim CW, Kim HG, Chung JW, Incheon and Western Kyonggi Gastrointestinal Study Group

BACKGROUND/AIMS: The aim of this study was to investigate the effects of rebamipide on tight junction proteins in the esophageal mucosa in a rat model of gastroesophageal reflux disease (GERD). METHODS:...
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A Prospective Study of Eosinophilic Esophagitis and the Expression of Tight Junction Proteins in Patients with Gastroesophageal Reflux Disease Symptoms

Okimoto K, Arai M, Ishigami H, Saito K, Minemura S, Maruoka D, Matsumura , Nakagawa T, Katsuno T, Suzuki M, Nakatani Y, Yokosuka O

BACKGROUND/AIMS: Eosinophilic esophagitis (EoE) is often erroneously diagnosed as gastroesophageal reflux disease (GERD). The aim of this study is to investigate the prevalence of EoE and the expression of tight...
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Curcumin protects against the intestinal ischemia-reperfusion injury: involvement of the tight junction protein ZO-1 and TNF-alpha related mechanism

Tian S, Guo R, Wei S, Kong Y, Wei X, Wang W, Shi X, Jiang H

Present study aimed to investigate the eff ect of curcumin-pretreatment on intestinal I/R injury and on intestinal mucosa barrier. Thirty Wistar rats were randomly divided into: sham, I/R, and curcumin...
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Uterine expression of tight junctions in the Canine uterus

Ahn C, Shin DH, Lee D, Kang HY, Jeung EB

Tight junctions (TJs) form continuous intercellular contacts in intercellular junctions. TJs involve integral proteins such as occludin (OCLN) and claudins (CLDNs) as well as peripheral proteins such as zona occludens-1...
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Intestinal Permeability Regulation by Tight Junction: Implication on Inflammatory Bowel Diseases

Lee SH

Epithelial tight junctions (TJs) are the key structures regulating paracellular trafficking of macromolecules. The TJ is multi-protein complex that forms a selective permeable seal between adjacent epithelial cells and demarcates...
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Changes of Tight Junction and Epithelial Cells after Treatment of Cadmium

Lee SJ, Kim KY, Kim DJ, Chung YH, Kim SS, Lee WB, Cho DY, Sohn DS

  • KMID: 1512957
  • Korean J Phys Anthropol.
  • 2007 Mar;20(1):69-82.
Cadmium (Cd) affects cell proliferation, differentiation, apoptosis and other cellular activities and can cause numerous molecular lesions that would be relevant to carcinogenesis. The mechanism of adverse effects of Cd...
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Alpha-tocopherol Prevents H2O2-induced Tight Junction Occludin Disruption in Blood-Brain Barrier

Lee HS, Namkoong K, Yook KH, Ahn JS, Noh MS, Kim DJ, Chung YH, Kim SS, Lee WB, Kim KY

  • KMID: 1583642
  • Korean J Phys Anthropol.
  • 2006 Sep;19(3):223-233.
Vitamin E is the most important lipid-soluble antioxidant in humans. Although alpha-tocopherol is suggested that it has protective effect from many diseases, little is known about the prevention of occludin alteration...
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Differential Expression of the Tight Junction Protein, Occludin, in Brain Tumors

Kim CH, Cheong JH, Bak KH, Kim JM, Ko Y, Oh SJ

  • KMID: 2067195
  • J Korean Neurosurg Soc.
  • 2005 Jul;38(1):12-15.
OBJECTIVE: Cerebral edema develops in the brain tumors by loosening of the endothelial tight junction. Tight junction(TJ) proteins, such as occludin and claudin bind adjacent cells tightly. Authors examine the...
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Oxidative Stress Induced--Expression Changes of Zonular Occludens--1 in Tight Junction

Sohn D, Lee H, Kim D, Choi H, Lee K, Cho H, Kim S, Lee J, Jeong Y, Kim S, Lee W, Kim K

  • KMID: 1609551
  • Korean J Phys Anthropol.
  • 2004 Dec;17(4):281-288.
The homeostasis of microenvironment in central nervous system, essential for normal function, is maintained by blood-brain barrier (BBB). ZO-1 in tight junctions (TJs) plays an important role in maintaining BBB...
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Expressions of Tight Junction Protein Claudin-1 and Claudin-7 in Squamous Cell Carcinoma of the Uterine Cervix

Lee JW, Lee YY, Yang SY, Lee SJ, Kim CJ, Kim BG, Park CS, Lee JH, Bae DS

  • KMID: 2244927
  • Korean J Gynecol Oncol Colposc.
  • 2004 Mar;15(1):41-47.
OJECTIVE : Claudins have been shown to be up-regulated in various cancers and have been suggested as possible biomarkers and targets for cancer therapy. The aims of this study were...
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