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Engineered M13 Nanofiber Accelerates Ischemic Neovascularization by Enhancing Endothelial Progenitor Cells

Lee JH, Kim SW, Ji ST, Kim YJ, Jang WB, Oh JW, Kim J, Yoo SY, Beak SH, Kwon SM

Dysfunction or loss of blood vessel causes several ischemic diseases. Although endothelial progenitor cells (EPCs) are a promising source for cell-based therapy, ischemia-induced pathophysiological condition limits the recovery rate by...
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Increased Expression of Thymosin β₄ Is Independently Correlated with Hypoxia Inducible Factor-1α (HIF-1α) and Worse Clinical Outcome in Human Colorectal Cancer

Lee SY, Park MJ, Lee HK, Son HJ, Kim CN, Kim JH, Kang DW

BACKGROUND: Thymosin β₄ is a multi-functional hormone-like polypeptide, being involved in cell migration, angiogenesis, and tumor metastasis. This study was undertaken to clarify the clinicopathologic implications of thymosin β₄ expression...
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Thymosin Beta-4, Actin-Sequestering Protein Regulates Vascular Endothelial Growth Factor Expression via Hypoxia-Inducible Nitric Oxide Production in HeLa Cervical Cancer Cells

Ryu YK, Lee JW, Moon EY

Vascular endothelial growth factor (VEGF) is an important regulator of neovascularization. Hypoxia inducible nitric oxide (NO) enhanced the expression of VEGF and thymosin beta-4 (Tbeta4), actin sequestering protein. Here, we...
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Angiogenic effects of recombinant thymosin beta4 in a mouse hindlimb ischemia model

Moon JH, Lee JW, Kang JK

Recombinant thymosin beta4 (rTbeta4) has been reported to migrate and promote vascularization, wound-healing, and hair growth in a mouse hindlimb ischemia model of peripheral vascular disease. C57BL/6 mice (11-weeks-old) were...
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The expression of Thymosin beta4 with angiogenic factors in epithelial ovarian cancer

Kim A, Chung HW, Kim JI, Chun SH, Moon HS

  • KMID: 2273346
  • Korean J Obstet Gynecol.
  • 2008 May;51(5):518-526.
OBJECTIVE: The aim of this study was to determine thymosin beta4 expression in epithelial ovarian cancer compared to normal ovarian tissue. METHODS: Normal and pathologic ovarian tissues were obtained from healthy...
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The expression of annexin I and thymosin beta4 in cervical cancer

Lee YS, Chung HW, Moon HS

  • KMID: 2273315
  • Korean J Obstet Gynecol.
  • 2008 Mar;51(3):313-323.
OBJECTIVE: The aim of this study was to compare the expression of annexin I and thymosin beta4 in invasive cervical cancer including normal cervix and CIN. METHODS: In Ewha Womans University...
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Thymosin Alpha-1 in Combination with Pegylated Interferon and Ribavirin in Chronic Hepatitis C Patients Who have Failed to Prior Pegylated Interferon and Ribavirin Treatment

Baek YH, Lee SW, Yoo HS, Yoon HA, Kim JW, Kim YH, Kim HY, Han SY

  • KMID: 2284055
  • Gut Liver.
  • 2007 Jun;1(1):87-89.
Combination therapy with inteferon-alpha and ribavirin is an approved therapy for patients with chronic hepatitis C. However, even with the use of pegylated interferon, response rates are still poor in...
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Gene Expression Analysis of Megakaryocytes Derived from Human Umbilical Cord CD34(+) Cells by Thrombopoietin

Kim JA, Kim HL

  • KMID: 1572613
  • Genomics Inform.
  • 2005 Mar;3(1):8-14.
Although much is known about the molecular biology of platelets, the megakaryocytes' (MKs) molecular biology was not understood so well because of their rareness. By the cloning and characterization of...
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Change in the Gene Expression of HOS Cell Line by 17beta-Estradiol -Study using cDNA Array-

Yoo CI, Suh JT, Kim JI, Kim CM

  • KMID: 2199153
  • J Korean Orthop Res Soc.
  • 2000 Apr;3(1):78-95.
Osteoporosis is caused by the decrease in bone mass associated with disturbance in bone remodeling. Bone remodeling depends on the spatial and temporal coupling of bone formation by osteoblasts and...
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A Catalogue of Gene Expression Difference in Biliary Cirrhosis due to Biliary Atresia Using Differential Expressed Sequence Tags(EST) Screening

Choe BH, Lee HM, Kim MK, Kim JC

  • KMID: 1946275
  • J Korean Pediatr Soc.
  • 2000 Jan;43(1):60-69.
PURPOSE: Extrahepatic biliary atresia is the most common indication for liver transplantation in children, but the etiology of this disorders remains unknown. It would be very signficant to identify genes...
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Combined Therapy of Alfa-Interferon and Thymodulin on Children with Chronic Active Hepatitis B

Choe BH, Ko C

  • KMID: 2072556
  • Korean J Pediatr Gastroenterol Nutr.
  • 1998 Sep;1(1):79-89.
PURPOSE: Though many antiviral or immunomodulatory agents have been used in patients with chronic HBV hepatitis, interferon is considered to be the only effective therapeutic agent so far. Among immunomodulatory...
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