- Differential Activation of Ras/Raf/MAPK Pathway between Heart and Cerebral Artery in Isoproterenol-induced Cardiac Hypertrophy
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Kim H, Kim N, Joo H, Youm JB, Park WS, Warda M, Kang S, Thu VT, Khoa TM, Han J
- KMID: 1600113
- Korean J Physiol Pharmacol.
- 2005 Oct;9(5):299-304.
Cardiac hypertrophy contributes an increased risk to major cerebrovascular events. However, the molecular mechanisms underlying cerebrovascular dysfunction during cardiac hypertrophy have not yet been characterized. In the present study, we... -
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- Regional Differences in Mitochondrial Anti-oxidant State during Ischemic Preconditioning in Rat Heart
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Thu VT, Cuong DV, Kim N, Youm JB, Warda M, Park WS, Ko JH, Kim E, Han J
- KMID: 1512908
- Korean J Physiol Pharmacol.
- 2007 Apr;11(2):57-64.
Ischemic preconditioning (IPC) is known to protect the heart against ischemia/reperfusion (IR)-induced injuries, and regional differences in the mitochondrial antioxidant state during IR or IPC may promote the death or... -
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- NecroX-5 protects mitochondrial oxidative phosphorylation capacity and preserves PGC1alpha expression levels during hypoxia/reoxygenation injury
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Thu VT, Kim HK, Long LT, Nyamaa B, Song IS, Thuy TT, Huy NQ, Marquez J, Kim SH, Kim N, Ko KS, Rhee BD, Han J
- KMID: 2388677
- Korean J Physiol Pharmacol.
- 2016 Mar;20(2):201-211.
- doi: 10.4196/kjpp.2016.20.2.201
Although the antioxidant and cardioprotective effects of NecroX-5 on various in vitro and in vivo models have been demonstrated, the action of this compound on the mitochondrial oxidative phosphorylation system... -
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- NecroX-5 exerts anti-inflammatory and anti-fibrotic effects via modulation of the TNFα/Dcn/TGFβ1/Smad2 pathway in hypoxia/reoxygenation-treated rat hearts
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Thu VT, Kim HK, Long LT, Thuy TT, Huy NQ, Kim SH, Kim N, Ko KS, Rhee BD, Han J
- KMID: 2285603
- Korean J Physiol Pharmacol.
- 2016 May;20(3):305-314.
- doi: 10.4196/kjpp.2016.20.3.305
Inflammatory and fibrotic responses are accelerated during the reperfusion period, and excessive fibrosis and inflammation contribute to cardiac malfunction. NecroX compounds have been shown to protect the liver and heart... -
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