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Prediction of itching diagnostic marker through RNA sequencing of contact hypersensitivity and skin scratching stimulation mice models

Kim YW, Zhou T, Ko EA, Kim S, Lee D, Seo Y, Kwon N, Choi T, Lim H, Cho S, Bae G, Hwang Y, Kim D, Park H, Lee M, Jang E, Choi J, Bae H, Lim I, Bang H, Ko JH

  • Korean J Physiol Pharmacol.
  • 2019 Mar;23(2):151-159.
  • doi: 10.4196/kjpp.2019.23.2.151
Pruritus (itching) is classically defined as an unpleasant cutaneous sensation that leads to scratching behavior. Although the scientific criteria of classification for pruritic diseases are not clear, it can be...
Far-infrared radiation stimulates platelet-derived growth factor mediated skeletal muscle cell migration through extracellular matrix-integrin signaling

Lee D, Seo Y, Kim YW, Kim S, Bae H, Choi J, Lim I, Bang H, Kim JH, Ko JH

  • Korean J Physiol Pharmacol.
  • 2019 Mar;23(2):141-150.
  • doi: 10.4196/kjpp.2019.23.2.141
Despite increased evidence of bio-activity following far-infrared (FIR) radiation, susceptibility of cell signaling to FIR radiation-induced homeostasis is poorly understood. To observe the effects of FIR radiation, FIR-radiated materials-coated fabric...
Dual deep neural network-based classifiers to detect experimental seizures

Jang HJ, Cho KO

  • Korean J Physiol Pharmacol.
  • 2019 Mar;23(2):131-139.
  • doi: 10.4196/kjpp.2019.23.2.131
Manually reviewing electroencephalograms (EEGs) is labor-intensive and demands automated seizure detection systems. To construct an efficient and robust event detector for experimental seizures from continuous EEG monitoring, we combined spectral...
Neuroprotective mechanisms of dieckol against glutamate toxicity through reactive oxygen species scavenging and nuclear factor-like 2/heme oxygenase-1 pathway

Cui Y, Amarsanaa , Lee JH, Rhim JK, Kwon JM, Kim SH, Park JM, Jung SC, Eun SY

  • Korean J Physiol Pharmacol.
  • 2019 Mar;23(2):121-130.
  • doi: 10.4196/kjpp.2019.23.2.121
Glutamate toxicity-mediated mitochondrial dysfunction and neuronal cell death are involved in the pathogenesis of several neurodegenerative diseases as well as acute brain ischemia/stroke. In this study, we investigated the neuroprotective...
Mannosylerythritol lipids ameliorate ultraviolet A-induced aquaporin-3 downregulation by suppressing c-Jun N-terminal kinase phosphorylation in cultured human keratinocytes

Bae IH, Lee SH, Oh S, Choi H, Marinho PA, Yoo JW, Ko JY, Lee ES, Lee TR, Lee CS, Kim DY

  • Korean J Physiol Pharmacol.
  • 2019 Mar;23(2):113-120.
  • doi: 10.4196/kjpp.2019.23.2.113
Mannosylerythritol lipids (MELs) are glycolipids and have several pharmacological efficacies. MELs also show skin-moisturizing efficacy through a yet-unknown underlying mechanism. Aquaporin-3 (AQP3) is a membrane protein that contributes to the...
Beneficial effects of andrographolide in a rat model of autoimmune myocarditis and its effects on PI3K/Akt pathway

Zhang Q, Hu LQ, Li HQ, Wu J, Bian NN, Yan G

  • Korean J Physiol Pharmacol.
  • 2019 Mar;23(2):103-111.
  • doi: 10.4196/kjpp.2019.23.2.103
The study is to investigate effects of andrographolide on experimental autoimmune myocarditis (EAM). Lewis rats were immunized on day 0 with porcine cardiac myosin to establish EAM. The EAM rats...
Involvement of Orai1 in tunicamycin-induced endothelial dysfunction

Yang H, Xue Y, Kuang S, Zhang M, Chen J, Liu L, Shan Z, Lin Q, Li X, Yang M, Zhou H, Rao F, Deng C

  • Korean J Physiol Pharmacol.
  • 2019 Mar;23(2):95-102.
  • doi: 10.4196/kjpp.2019.23.2.95
Endoplasmic reticulum (ER) stress is mediated by disturbance of Ca²⁺ homeostasis. The store-operated calcium (SOC) channel is the primary Ca²⁺ channel in non-excitable cells, but its participation in agent-induced ER...

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