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10 results

Effects of Losartan on Catecholamine Release in the Isolated Rat Adrenal Gland

Noh HJ, Kang YS, Lim DY

  • Korean J Physiol Pharmacol.
  • 2009 Aug;13(4):327-335.
  • doi: 10.4196/kjpp.2009.13.4.327
The aim of this study was to determine whether losartan, an angiotensin II (Ang II) type 1 (AT1) receptor could influence the CA release from the isolated perfused model of...
Antioxidant Effect of CoQ10 on N-nitrosodiethylamine-induced Oxidative Stress in Mice

Song HS, Kim HR, Park TW, Cho BJ, Choi MY, Kim CJ, Sohn UD, Sim SS

  • Korean J Physiol Pharmacol.
  • 2009 Aug;13(4):321-326.
  • doi: 10.4196/kjpp.2009.13.4.321
The antioxidant effect of CoQ10 on N-nitrosodiethylamine (NDEA)-induced oxidative stress was investigated in mice. Food intake and body weight were similar in both CoQ10 and control groups during the 3-week...
The Effects of Astragalus Membranaceus on Repeated Restraint Stress-induced Biochemical and Behavioral Responses

Park HJ, Kim HY, Yoon KH, Kim KS, Shim I

  • Korean J Physiol Pharmacol.
  • 2009 Aug;13(4):315-319.
  • doi: 10.4196/kjpp.2009.13.4.315
Astragalus Membranaceus (AM) is a useful Korean herb that has been clinically prescribed for stress-related illness. The objective of the present study was to examine the anti-stress effects of AM...
Heme Oxygenase-1 Induced by Aprotinin Inhibits Vascular Smooth Muscle Cell Proliferation Through Cell Cycle Arrest in Hypertensive Rats

Choi HC, Lee KY, Lee DH, Kang YJ

  • Korean J Physiol Pharmacol.
  • 2009 Aug;13(4):309-313.
  • doi: 10.4196/kjpp.2009.13.4.309
Spontaneous hypertensive rats (SHR) are an established model of genetic hypertension. Vascular smooth muscle cells (VSMC) from SHR proliferate faster than those of control rats (Wistar-Kyoto rats; WKY). We tested...
DHA and EPA Down-regulate COX-2 Expression through Suppression of NF-kappa B Activity in LPS-treated Human Umbilical Vein Endothelial Cells

Lee SA, Kim HJ, Chang KC, Baek JC, Park JK, Shin JK, Choi WJ, Lee JH, Paik WY

  • Korean J Physiol Pharmacol.
  • 2009 Aug;13(4):301-307.
  • doi: 10.4196/kjpp.2009.13.4.301
Inflammatory processes of vascular endothelial cells play a key role in the development ofatherosclerosis. We determined the anti-inflammatory effects and mechanisms of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on...
The Inhibitory Effect of Quercetin-3-O-beta-D-Glucuronopyranoside on Gastritis and Reflux Esophagitis in Rats

Min YS, Lee SE, Hong ST, Kim HS, Choi BC, Sim SS, Whang WK, Sohn UD

  • Korean J Physiol Pharmacol.
  • 2009 Aug;13(4):295-300.
  • doi: 10.4196/kjpp.2009.13.4.295
It was evaluated the inhibitory action of quercetin-3-O-beta-D-glucuronopyranoside (QGC) on reflux esophagitis and gastritis in rats. QGC was isolated from the herba of Rumex Aquaticus. Reflux esophagitis or gastritis was...
Inhibition of Arterial Myogenic Responses by a Mixed Aqueous Extract of Salvia Miltiorrhiza and Panax Notoginseng (PASEL) Showing Antihypertensive Effects

Baek EB, Yoo HY, Park SJ, Chung YS, Hong EK, Kim SJ

  • Korean J Physiol Pharmacol.
  • 2009 Aug;13(4):287-293.
  • doi: 10.4196/kjpp.2009.13.4.287
The dried roots of Danshen (Salvia miltiorrhiza) and Sanchi (Panax notoginseng) have been widely used in traditional Chinese medicine for promoting blood circulation as well as various other bodily functions....
Naringin Protects against Rotenone-induced Apoptosis in Human Neuroblastoma SH-SY5Y Cells

Kim HJ, Song JY, Park HJ, Park HK, Yun DH, Chung JH

  • Korean J Physiol Pharmacol.
  • 2009 Aug;13(4):281-285.
  • doi: 10.4196/kjpp.2009.13.4.281
Rotenone, a mitochondrial complex I inhibitor, can induce the pathological features of Parkinson's disease (PD). In the present study, naringin, a grapefruit flavonoid, inhibited rotenone-induced cell death in human neuroblastoma...
Inhibition of beta-amyloid(1-40) Peptide Aggregation and Neurotoxicity by Citrate

Park YH, Kim YJ, Son IH, Yang HD

  • Korean J Physiol Pharmacol.
  • 2009 Aug;13(4):273-279.
  • doi: 10.4196/kjpp.2009.13.4.273
The accumulation of beta-amyloid (A beta) aggregates is a characteristic of Alzheimer's disease (AD). Furthermore, these aggregates have neurotoxic effects on cells, and thus, molecules that inhibit A beta aggregate...
Kainic Acid-induced Neuronal Death is Attenuated by Aminoguanidine but Aggravated by L-NAME in Mouse Hippocampus

Byun JS, Lee SH, Jeon SH, Kwon YS, Lee HJ, Kim SS, Kim YM, Kim MJ, Chun W

  • Korean J Physiol Pharmacol.
  • 2009 Aug;13(4):265-271.
  • doi: 10.4196/kjpp.2009.13.4.265
Nitric oxide (NO) has both neuroprotective and neurotoxic effects depending on its concentration and the experimental model. We tested the effects of NG-nitro-L-arginine methyl ester (L-NAME), a nonselective nitric oxide...

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