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Nitric Oxide Donor, NOR-3, Increased Expression of Cyclooxygenase-2, but not of Cyclooxygenase-1 in Cultured VSMC

Lee DH, Park JE, Kang YJ, Lee KY, Choi HC

  • Korean J Physiol Pharmacol.
  • 2006 Jun;10(3):161-165.
NO and cyclooxygenase-2 (COX-2) are contributes to vascular inflammation induced by various stimulation. The mechanism, which explains a linkage between NO and COX-2, could be of importance in promoting pathophysiological...
p66shc Adaptor Protein Suppresses the Activation of Endothelial Nitric Oxide Synthase in Mouse Embryonic Fibroblasts

Lee SK, Kim YS, Kim CS, Son SJ, Yoo DG, Lee KH, Lee SD, Park JB, Jeon BH

  • Korean J Physiol Pharmacol.
  • 2006 Jun;10(3):155-159.
Among the Shc proteins, p66shc is known to be related to oxidative stress responses and regulation of the production of reactive oxygen species (ROS). The present study was undertaken to...
Effects of Phosphodiesterase 5 Inhibition with Sildenafil on Atrial Contractile and Secretory Function

Quan HX, Kim SY, Jin XS, Park JK, Kim SZ, Cho KW

  • Korean J Physiol Pharmacol.
  • 2006 Jun;10(3):149-154.
Selective inhibition of phosphodiesterase (PDE) 5 opened a new therapeutic approach for cardiovascular disorders. Therefore, the effect of PDE5 inhibition on the cardiac function should thoroughly be defined. The purpose...
Carthamus tinctorius L. Increases BMP-2 Gene Expression during Bone Fracture Healing in Rats

Lee KH, Sohn OJ, Ahn JC, Kim YW, Park SY, Kim JY

  • Korean J Physiol Pharmacol.
  • 2006 Jun;10(3):143-147.
Carthamus tinctorius L.is known to improve fracture healing, and bone morphogenetic proteins (BMPs) are associated with the formation and healing process of bone. BMP-2 and BMP-7 are two of the...
Changes of Hemodynamics and Renal Function due to Acute Cadmium Exposure in Rats

Kim JJ, Kim YK

  • Korean J Physiol Pharmacol.
  • 2006 Jun;10(3):137-141.
The systolic and diastolic pressures in anesthetized Sprague-Dawley male rats were greatly decreased after single-dose of Cd treatment without significant changes in heart rate. There was a fluid-shift into the...
Effects of Phenylephrine on the Excitability of Medial Vestibular Nuclear Neurons in Rats

Jeong HS, Huh HR, Jang MJ, Hong SH, Jang S, Park J, Lee SH, Kim JH, Park JS

  • Korean J Physiol Pharmacol.
  • 2006 Jun;10(3):131-135.
Coeruleo-vestibular pathway which connects locus coeruleus and vestibular nuclei is noradrenergic. This study was designed to elucidate the effects of phenylephrine on the spontaneous activity of acutely isolated medial vestibular...
Estrogen Pretreatment of Organotypic Hippocampal Slices Protects Neurons against Oxygen-Glucose Deprivation with Akt Activation

Park EM, Hong S, Lee KE

  • Korean J Physiol Pharmacol.
  • 2006 Jun;10(3):123-129.
In several experimental models, estrogens protect neurons against ischemic insults. However, the recent clinical studies of hormone replacement showed negative results to prevent stroke. Therefore, optimal models to study estrogen...
Neuroprotective Effects of Lithium on NMDA-induced Excitotoxicity in Mouse Cerebrum

Kwon GY, Kim SK

  • Korean J Physiol Pharmacol.
  • 2006 Jun;10(3):111-121.
Neuroprotective properties of lithium were evaluated by using in vivo NMDA excitotoxicity model. Systemic injection of NMDA to young mice induced neuronal apoptosis mediated by both TNFR-1 and Fas ligand,...

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