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A Simple and Sensitive Assay for Cefepime in Human Plasma Using High Performance Liquid Chromatography

Kim YS, Yim DS, Lee DG, Lee SB

  • Korean J Physiol Pharmacol.
  • 2003 Aug;7(4):247-250.
A simple and sensitive assay method was developed for cefepime in human plasma using high performance liquid chromatography (HPLC). Cefepime and cefadroxil (the internal standard) were extracted from heparinized human...
Salicylate Regulates Cyclooxygenase-2 Expression through ERK and Subsequent NF-kappaB Activation in Osteoblasts

Chae HJ, Lee JK, Byun JO, Chae SW, Kim HR

  • Korean J Physiol Pharmacol.
  • 2003 Aug;7(4):239-246.
The expression of cyclooxygenase-2 (COX-2) is a characteristic response to inflammation and can be inhibited with sodium salicylate. TNF-alpha plus IFN-gamma can induce extracellular signal-regulated kinase (ERK), IKK, IkappaB degradation...
Influence of Bradykinin on Catecholamine Release from the Rat Adrenal Medulla

Lim DY, Kim IH, Na GM, Kang MJ, Kim OM, Choi DH, Ki YW

  • Korean J Physiol Pharmacol.
  • 2003 Aug;7(4):231-238.
The present study was undertaken to investigate the effect of bradykinin on secretion of catecholamines (CA) evoked by stimulation of cholinergic receptors and membrane depolarization from the isolated perfused model...
Enhancement of ATP-induced Currents by Phospholipase D1 Overexpressed in PC12 Cells

Park JB, Kim YR, Jeon BH, Park SK, Oh SO, Kim YG, Lee SD, Kim KJ

  • Korean J Physiol Pharmacol.
  • 2003 Aug;7(4):223-230.
Using phospholipase D1 (PLD1) -overexpressing PC12 (PLD1-PC12) cells, the regulatory roles of PLD1 on ATP-induced currents were investigated. In control and PLD1-PC12 cells, ATP increased PLD activity in an external...
Roles of Gonadal Steroids on Exocrine Secretion of Isolated Perfused Rat Pancreas

Park HS, Kim SH, Park HJ, Lee MY, Han YH

  • Korean J Physiol Pharmacol.
  • 2003 Aug;7(4):217-222.
To clarify the roles of gonadal steroids on pancreatic exocrine secretion, effects of progesterone and estradiol-17beta on spontaneous and secretagogue-induced exocrine response of isolated perfused rat pancreas were investigated. Intra-arterial...
Comparative Analysis of Phospholipase D2 Localization in the Pancreatic Islet of Rat and Guinea Pig

Ryu GR, Kim MJ, Song CH, Min DS, Rhie DJ, Yoon SH, Hahn SJ, Kim MS, Jo YH

  • Korean J Physiol Pharmacol.
  • 2003 Aug;7(4):211-216.
To examine the localization pattern of phospholipase D2 (PLD2) in the pancreatic islet (the islet of Langerhans) depending on species, we conducted a morphological experiment in the rat and guinea...
Fuctional Relationship between Rate of Fatty Acid Oxidation and Carnitine Palmitoyl Transferase I Activity in Various Rat Tissues

Cho YL, Do KO, Kwon TD, Jang EC, Lee KM, Lee SK, Kim JY

  • Korean J Physiol Pharmacol.
  • 2003 Aug;7(4):207-210.
Lipids play many structural and metabolic roles, and dietary fat has great impact on metabolism and health. Fatty acid oxidation rate is dependent on tissue types. However there has been...
PDTC Inhibits TNF-alpha-Induced Apoptosis in MC3T3E1 Cells

Chae HJ, Bae J, Chae SW

  • Korean J Physiol Pharmacol.
  • 2003 Aug;7(4):199-206.
Osteoblasts are affected by TNF-alpha overproduction by immune cells during inflammation. It has been suggested that functional NF-kappaB sites are involved in TNF-alpha-induced bone resorption. Thus, we explored the effect...
Responses of Inferior Olive Neurons to Stimulation of Semicircular Canals. II. Vertical Semicircular Canalss

Park SH, Park JS, Park JS

  • Korean J Physiol Pharmacol.
  • 2003 Aug;7(4):193-198.
In the present study, the vestibularly evoked activity of inferior olive (IO) neurons was examined to investigate the vertical vestibular information transmitted through the vestibulo-olivo-cerebellar climbing fiber pathway. The extracellular...

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