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Increased response of hypogastric nerve fibers to bradykinin by mustard oil-induced uterine inflammation in the rat

Seo BK, Cho JS, Lee MG, Lee SE, Han HC, Yoon YW, Hong SK

  • Korean J Physiol Pharmacol.
  • 2001 Feb;5(1):99-105.
It is well known that the inflammation of somatic tissues, bladder and colon can alter the sensitivity of primary afferents innervating these tissues. To see if uterine afferents also show altered sensitivity,...
The hyperthermic effect of nitric oxide in central nervous system

Jung JK, Sohn UD, Lee SY

  • Korean J Physiol Pharmacol.
  • 2001 Feb;5(1):93-98.
The precise mechanism of set-point regulation in hypothalamus was not elucidated. Nitric oxide synthases (NOS) were detected in hypothalamus, however, the roles of NO in hypothalamus was not fully studied. So, we tested...
Effect of heme oxygenase induction by NO donor on the aortic contractility

Kim CK, Sohn UD, Lee SY

  • Korean J Physiol Pharmacol.
  • 2001 Feb;5(1):87-92.
Carbon monoxide (CO) binds to soluble guanylate cyclase to lead its activation and elicits smooth muscle relaxation. The vascular tissues have a high capacity to produce CO, since heme oxygenase-2 (HO-2) is constitutively...
Differentiation induction of dendritic cell phenotypes from human leukemic cell lines

Lee DH, Park JS, Eo WK, Kim WM, Kang K

  • Korean J Physiol Pharmacol.
  • 2001 Feb;5(1):79-86.
Recent clinical studies have shown that a high proportion of patients with acute promyelocytic leukemia (APL) achieve complete remission after treatment with all-trans retinoic acid (ATRA). However, most patients who receive continuous treatment...
DAMGO, a micro-opioid agonist and cholecystokinin-octapeptide have dual modulatory effects on capsaicin-activated current in rat dorsal root ganglion neurons

Eun SY, Kim J, Lee J, Jung SJ, Park JM, Park YK, Kim D, Kim SJ, Kwak J, Kim J

  • Korean J Physiol Pharmacol.
  • 2001 Feb;5(1):71-78.
Capsaicin, a pungent ingredient of hot pepper, elicits an intense burning pain when applied cutaneously and intradermally. Activation of capsaicin-gated channel in. C-type dorsal root ganglion (DRG) neurons produces nonselective cationic currents. Although...
Increased expression of nitric oxide synthases in left and right ventricular hypertrophy

Lee JU, Oh YW, Kim S, Kang DG, Lee WJ

  • Korean J Physiol Pharmacol.
  • 2001 Feb;5(1):65-70.
The present study was aimed to explore pathophysiological implications of nitric oxide in the development of left and right ventricular hypertrophy. To induce selective left and right ventricular hypertrophy, rats were made two-kidney,...
Role of NF- kappaB binding sites in the regulation of inducible nitric oxide synthase by tyrosine kinase

Ryu YS, Hong JH, Lim JH, Bae SH, Ahn IS, Seok JH, Lee JH, Hur GM

  • Korean J Physiol Pharmacol.
  • 2001 Feb;5(1):55-63.
In macrophages, lipopolysaccharide (LPS) alone or in combination with interferon- gamma (IFN- gamma) has been shown to release a nitric oxide (NO) through the increase of the transcription of the inducible nitric oxide...
Pulse exposure to ethanol augments vascular contractility through stress response

Yang EK, Kim IK

  • Korean J Physiol Pharmacol.
  • 2001 Feb;5(1):47-53.
Drinking excessive alcohol has been recognized as a risk factor for hypertension. However, the mechanism by which alcohol intake causes hypertension still remains elusive. We tested the hypothesis that ethanol itself acts as...
Role of angiotensin II and nitric oxide in the rat paraventricular nucleus

Yang EK

  • Korean J Physiol Pharmacol.
  • 2001 Feb;5(1):41-46.
To investigate the mutual relationship between angiotensin II (Ang II) and nitric oxide (NO) in paraventricular nucleus (PVN), Ang II receptor type Ia (AT1A), type Ib (AT1B), endothelial constitutive nitric oxide synthase (ecNOS),...
Altered delayed rectifier K+ current of rabbit coronary arterial myocytes in isoproterenol-induced hypertrophy

Kim N, Han J, Kim E

  • Korean J Physiol Pharmacol.
  • 2001 Feb;5(1):33-40.
The aim of present study was to define the cellular mechanisms underlying changes in delayed rectifier K+ (KDR) channel function in isoproterenol-induced hypertrophy. It has been proposed that KDR channels play a role...
Changes of afferent transmission to the SI cortex by transient co-stimulation of receptive field center and outside in anesthetized rats

Yang YM, Lim S, Won CK, Shin HC

  • Korean J Physiol Pharmacol.
  • 2001 Feb;5(1):27-32.
We have characterized the aftereffects of impulse activities on the transmission of afferent sensory to the primary somatosensory (SI) cortex of the anesthetized rats (n=22). Following conditioning stimulation (CS, 10 sec, either 5...
Regulation of immediate early gene expression by glutamate receptor activation in C6 rat glioma cells

Lee JK, Kim YH, Choi SS, Suh HW

  • Korean J Physiol Pharmacol.
  • 2001 Feb;5(1):19-25.
We have studied the effects of excitatory amino acids on the expression of the c-fos and c-jun mRNA in rat C6 glioma cells. The glutamate, N-methyl-D-aspartate (NMDA), and kainic acid (KA) increased...
Differentiation of neuroepithelial progenitor cells implanted into newborn rat brain striatum

Kwon SC, Park JS, Lee JJ, Nam TS, Yeon DS

  • Korean J Physiol Pharmacol.
  • 2001 Feb;5(1):9-17.
It has been demonstrated that multipotent neuronal progenitor cells can be isolated from the developing or adult CNS and proliferated in vitro in response to epidermal growth factor. The present study was undertaken...
Role of gap junctions in the endothelium-dependent hyperpolarization of vascular smooth muscle cells

Yamamoto Y, Klemm MF, Hashitani , Lang JR, Soji T, Suzuki H

  • Korean J Physiol Pharmacol.
  • 2001 Feb;5(1):1-8.
Hyperpolarization of arterial smooth muscle by acetylcholine is considered to be produced by the release of an unidentified chemical substance, an endothelium-derived hyperpolarizing factor (EDHF). Several chemicals have been proposed as the candidate...

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