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13 results

Angiotensin-converting enzyme gene polymorphism is not associated with myocardial infarction in Koreans

Chai S, Sohn DR

  • Korean J Physiol Pharmacol.
  • 1998 Oct;2(5):645-650.
To assess the relationship between angiotensin-converting enzyme (ACE) gene polymorphism and myocardial infarction in Koreans, we recruited 112 healthy, unrelated subjects (mean age 53.4 years) and 104 myocardial infarction survivors (mean age 54.2...
Further characterization of bombesin like immunoreactivities from the skin of Korean fire-bellied toad, Bombina orientalis

Kwon HY, Park HS, Won MH, Lee YL, Park JH

  • Korean J Physiol Pharmacol.
  • 1998 Oct;2(5):637-644.
Previously, we have isolated authentic bombesin and another bombesin like peptide named bombesin like immunoreactivity (BLI)-K2 from the skin of Korean fire-bellied toad, Bombina orientalis. In the present study, we have newly purified...
Effects of small molecular antioxidants on cerulein-induced acute pancreatitis in rat

Choi JY, Kim KH

  • Korean J Physiol Pharmacol.
  • 1998 Oct;2(5):629-635.
It has been suggested that oxygen free radicals are involved in the initiation process of acute pancreatitis, although its pathogenesis is not clear. This study evaluates the roles of oxygen radicals and...
Effect of the inhibition of PLA 2 on oxidative lung injury induced by interleukin-1alpha

Lee YM, Cho HG, Park YY, Kim JK, Lee YJ, Park WH, Kim T

  • Korean J Physiol Pharmacol.
  • 1998 Oct;2(5):617-628.
In order to understand the pathogenetic mechanism of adult respiratory distress syndrome (ARDS), the role of phospholipase A2 (PLA2) in association with oxidative stress was investigated in rats. Interleukin-1alpha (IL-1, 50 mug/rat) was...
The role of intracellular Mg2+ in regulation of Ca2+-activated K+ channel in pulmonary arterial smooth muscle cells of the rabbit

Lee SH, Park MK

  • Korean J Physiol Pharmacol.
  • 1998 Oct;2(5):611-616.
Although the Ca2+-activated K+ (IK,Ca) channel is known to play an important role in the maintenance of resting membrane potential, the regulation of the channel in physiological condition is not completely understood in...
Role of phospholipase A2 in oxidant-induced alteration in phosphate transport in primary cultured rabbit renal proximal tubule cells

Park KM, Ko SH, Woo JS, Jung JS, Lee SH, Kim YK

  • Korean J Physiol Pharmacol.
  • 1998 Oct;2(5):601-609.
The present study was undertaken to examine the role of phospholipase A2 (PLA2) in oxidant-induced inhibition of phosphate transport in primary cultured rabbit renal proximal tubule cells. Uptakes of phosphate and glucose were...
The effects of aging and atherosclerosis on elastin of human aortas; quantitative analysis of elastin-content and SEM analysis of elastolysis.

Song SH, Roach MR

  • Korean J Physiol Pharmacol.
  • 1998 Oct;2(5):591-600.
We have examined 24 human aortas aged 46 ~ 90 years obtained from autopsies. Most exhibited gross lesions of some degree on the lumenal surface. Using hot alkaline treatment (0.1 N NaOH)...
The effects of intracellular monocarboxylates on the ATP-sensitive potassium channels in rabbit ventricular myocytes

Kim N, Han J, Kim YE, Ho WK, Earm YE

  • Korean J Physiol Pharmacol.
  • 1998 Oct;2(5):581-589.
A regulating mechanism of the ATP-sensitive potassium channels (KATP channels) is yet to fully explained. This study was carried out to investigate the effects of intracellular application of monocarboxylates (acetate, formate, lactate, and...
Altered cerebral vasomotion with decreased CGRP level in pial arteries of spontaneously hypertensive rats

Lee KH, Choi JM, Hong KW

  • Korean J Physiol Pharmacol.
  • 1998 Oct;2(5):573-580.
The study aims to identify the mechanism (s) underlying the altered vasodilatory responses of the pial artery of spontaneously hypertensive rats (SHR) under a hypothesis that calcitonin gene-related peptide (CGRP) exerts a modulator...
Effect of bromocriptine on 6-hydroxydopamine-induced lipid peroxidation and cytotoxicity in vitro and in vivo

Kim YS, Maeng S, Park CW

  • Korean J Physiol Pharmacol.
  • 1998 Oct;2(5):565-572.
The present study was to evaluate the protective effects of bromocriptine, which is known as D2 dopamine receptor agonist and used for the treatment of patients with Parkinson's disease (PD), on 6-hydroxydopamine (6-OHDA)-induced...
Natriuresis induced by intracerebroventricular diazepam in rabbits

Koh JT, Kook YJ

  • Korean J Physiol Pharmacol.
  • 1998 Oct;2(5):555-563.
The renal function is under regulatory influence of central nervous system (CNS), in which various neurotransmitter and neuromodulator systems take part. However, a possible role of central GABA-benzodiazepine system on the central regulation...
Dual action of d-tubocurarine on large-conductance Ca2+-activated K+ channels from rat brain reconstituted into planar lipid bilayer

Chung S, Shin JH

  • Korean J Physiol Pharmacol.
  • 1998 Oct;2(5):549-553.
Using the planar lipid bilayer method, we investigated the effect of d-tubocurarine (dTC) on the extracellular side of large-conductance Ca2+-activated K+ channel from rat brain. When the initial open probability (Po) of the...
Regulation of salt and volume transport along the nephron during acute systolic hypertension

McDonough , Zhang Y, Magyar CE, Mircheff A

  • Korean J Physiol Pharmacol.
  • 1998 Oct;2(5):541-547.
DISCUSSION Acute regulation of sodium pump activity There is a burgeoning literature on mechanisms responsible for short term regulation of Na,K-ATPase activity (Aperia et al, 1996, 1994; Boron et al,...

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