- Potential for Dependence on Lisdexamfetamine - In vivo and In vitro Aspects
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Yun J, Lee KW, Eom JH, Kim YH, Shin J, Han K, Park HK, Kim HS, Cha HJ
- KMID: 2395816
- Biomol Ther.
- 2017 Nov;25(6):659-664.
- doi: 10.4062/biomolther.2016.080
Although lisdexamfetamine is used as a recreational drug, little research exists regarding its potential for dependence or its precise mechanisms of action. This study aims to evaluate the psychoactivity and... -
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- Antioxidant effects of serotonin and L-DOPA on oxidative damages of brain synaptosomes
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Ham SS, Kim DH, Lee SH, Kim YS, Lee CS
- KMID: 1554130
- Korean J Physiol Pharmacol.
- 1999 Apr;3(2):147-155.
Antioxidant effects of serotonin and L-DOPA on neuronal tissues were examined by studying the oxidative damages of brain synaptosomal components. The study further explored the mechanism by which they exert protective actions. Serotonin... -
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- Effect of Ca2+-channel Blockers on Norepinephrine Release in the Rat Hippocampal Slice and Synaptosome
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Kim SW, Jung KY, Choi BK
- KMID: 1614995
- Korean J Physiol Pharmacol.
- 2002 Apr;6(2):87-92.
The aim of this study was to investigate the role of Ca2+-channel blockers in norepinephrine (NE) release from rat hippocampus. Slices and synaptosomes were incubated with [3H]-NE and the releases... -
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- Inhibitory Effect of Tyrphostin AG126 on Brain Synaptosomal Dysfunction Induced by Cholesterol Oxidation Products
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Hong KM, Han JH, Kim DE, Song JH, Lee CS
- KMID: 2185067
- J Korean Neurol Assoc.
- 2008 Aug;26(3):231-238.
BACKGROUND: Formation of cholesterol oxidation products is a suggested mechanism of neurodegenerative disorders. Neuronal cell death is mediated by an increased release of excitotoxic glutamate from the presynaptic nerve endings.... -
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- Effect of t-butylhydroperoxide on Na+/-dependent glutamate uptake in rabbit brain synaptosome
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Lee HJ, Kim YK
- KMID: 2071508
- Korean J Physiol Pharmacol.
- 1997 Aug;1(4):367-376.
The effect of an organic peroxide, t-butylhydroperoxide (t-BHP), on glutamate uptake was studied in synaptosomes prepared from cerebral cortex. t-BHP inhibited the Na+/-dependent glutamate uptake with no change in the Na+/-independent uptake. This... -
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- Lithium-induced inhibition of Na-K ATPase and Ca ATPase activities in rat brain synaptosome
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Cho YW
- KMID: 1129859
- J Korean Med Sci.
- 1995 Feb;10(1):7-13.
- doi: 10.3346/jkms.1995.10.1.7
To explore the action mechanism of lithium in the brain, the author investigated the effects of lithium on Na-K ATPase and Ca ATPase in rat brain synaptosomes prepared from forebrains... -
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- Effect of Carbon Monoxide-Induced Hypoxia on Synaptosomal Uptake and Release of Dopamine in Rat Striatum
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Chai KJ, Bae SK
- KMID: 1119201
- Yonsei Med J.
- 1988 Jun;29(2):129-138.
- doi: 10.3349/ymj.1988.29.2.129
We studied the effect of carbon monoxide (CO)-induced hypoxia on synaptosomal uptake and release of dopamine (DA) in rat striatum. When the rats were intoxicated at a blood level of... -
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- Lithium-induced increase of synaptosomal uptake of norepinephrine in rat brain
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Cho YW, Han SH, Kim CJ, Min BI
- KMID: 1554548
- Korean J Physiol Pharmacol.
- 1997 Apr;1(2):127-133.
Lithium remains the most widely used therapeutic agent for bipolar affective disorder, particularly mania. Although many investigators have studied the effects of lithium on abnormalities in monoamine neurotransmitter as a pathophysiological basis of... -
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- Synapsin-1 and tau reciprocal O-GlcNAcylation and phosphorylation sites in mouse brain synaptosomes
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Kang MJ, Kim C, Jeong H, Cho BK, Ryou AL, Hwang D, Mook-Jung , Yi EC
- KMID: 2154248
- Exp Mol Med.
- 2013 Jun;45(6):e29.
O-linked N-acetylglucosamine (O-GlcNAc) represents a key regulatory post-translational modification (PTM) that is reversible and often reciprocal with phosphorylation of serine and threonine at the same or nearby residues. Although recent... -
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- The Role of 5-HT Receptors on the Acetylcholine Release from the Rat Striatum
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Joo YH, Jung KY, Choi BK
- KMID: 1607282
- Korean J Psychopharmacol.
- 2001 Jun;12(2):140-146.
The aim of this study was to investigate the role of the 5-HT receptors in acetylcholine (ACh) release from the striatum. Slices from the rat striatum and synaptosomes were incubated... -
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- Interaction of Sodium Selenite on Neurotoxicity Induced by Methylmercuric Chloride
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Park JS, Lee HM, Chung Y, Shin DC, Roh JH, Moon YH
- KMID: 2282585
- Korean J Prev Med.
- 1992 Mar;25(1):13-25.
This study was conducted to investigate the mechanism of protective effect by sodium selenite in Methylmercuric chloride neurotoxicity, increasing intracellular Ca2+ concentration of the neuron. Methylmercuric chloride of 3 mg/kg... -
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- Regulation of GTP-binding state in RalA through Ca2+ and calmodulin
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Park JB
- KMID: 755118
- Exp Mol Med.
- 2001 Mar;33(1):54-58.
RalA GTPase, a member of Ras superfamily proteins, shows alternative forms between the active GTP-binding and the inactive GDP-binding states. Ral-specific guanine nucleotide exchange factor such as RalGDS interacts with... -
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- Effects of Heavy Metals in Transport of GABA in Cat Brain Synaptosome
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Lee YW
- KMID: 1673069
- J Korean Neurosurg Soc.
- 1994 Aug;23(8):876-884.
The administration of Aluminium had shown the result of neurofibrillary degeneration in encephalopathy of Alzhheimer's desease and cadmium chloride caused the damage of cells of the cerebral cortex. The neurological... -
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- The proteins of synaptic vesicle membranes are affected during ageing of rat brain
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Lee SR, Kim AR, Kim JS, Kim JB, Lee JY, Lee YL, Choe M, Park JB
- KMID: 1457533
- Exp Mol Med.
- 2001 Dec;33(4):220-225.
Low molecular weight GTP-binding proteins are molecular switches that are believed to play pivotal roles in cell growth, differentiation, cytoskeletal organization, and vesicular trafficking. Rab proteins are key players in... -
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- A Study for the Expression of the N-Methyl-D-Aspartate (NMDA) Subunit 2A(NR2A) and 2B(NR2B) of Rat Hippocampal Slices in the Hypoxic State
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Go HS, Kim WT
- KMID: 2208204
- J Korean Pediatr Soc.
- 1996 Sep;39(9):1295-1308.
PURPOSE: Excessive amounts of glutamate are released into the extracelluar space during hypoxia/ischemia and contribute to neuronal injury through overactivation of the NMDA receptors. It will be expected that the... -
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