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Sumoylation of Hes6 Regulates Protein Degradation and Hes1-Mediated Transcription

Lee J, Chun SK, Son GH, Kim K

BACKGROUND: Hes6 is a transcriptional regulator that induces transcriptional activation by binding to transcription repressor Hes1 and suppressing its activity. Hes6 is controlled by the ubiquitin-proteosome-mediated degradation system. Here we...
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Sumoylation of histone deacetylase 1 regulates MyoD signaling during myogenesis

Joung H, Kwon S, Kim KH, Lee YG, Shin S, Kwon DH, Lee YU, Kook T, Choe N, Kim JC, Kim YK, Eom GH, Kook H

Sumoylation, the conjugation of a small ubiquitin-like modifier (SUMO) protein to a target, has diverse cellular effects. However, the functional roles of the SUMO modification during myogenesis have not been...
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SUMO Proteins are not Involved in TGF-beta1-induced, Smad3/4-mediated Germline alpha Transcription, but PIASy Suppresses it in CH12F3-2A B Cells

Lee SH, Kim PH, Oh SM, Park JH, Yoo YC, Lee J, Park SR

TGF-beta induces IgA class switching by B cells. We previously reported that Smad3 and Smad4, pivotal TGF-beta signal-transducing transcription factors, mediate germline (GL) alpha transcription induced by TGF-beta1, resulting in...
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An Immunohistochemical Study on the Expression of SUMO-2/3 in the Colorectal Carcinoma

Ham JH, Park J, Park DS, Lee SS, Yang SH, Jeong D

  • KMID: 2317655
  • Soonchunhyang Med Sci.
  • 2012 Dec;18(2):95-101.
OBJECTIVE: The incidence of colorectal carcinomas continues to rise in Korea due to the westernized life style. However, the precise colorectal carcinogenic mechanisms remain to be elucidated. The protein products...
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Modulation of the Transcriptional Activity of Peroxisome Proliferator-Activated Receptor Gamma by Protein-Protein Interactions and Post-Translational Modifications

Kim TH, Kim MY, Jo SH, Park JM, Ahn YH

Peroxisome proliferator-activated receptor gamma (PPARgamma) belongs to a nuclear receptor superfamily; members of which play key roles in the control of body metabolism principally by acting on adipose tissue. Ligands...
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