- Glia as a Link between Neuroinflammation and Neuropathic Pain
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Jha MK, Jeon S, Suk K
- KMID: 2150733
- Immune Netw.
- 2012 Apr;12(2):41-47.
- doi: 10.4110/in.2012.12.2.41
Contemporary studies illustrate that peripheral injuries activate glial components of the peripheral and central cellular circuitry. The subsequent release of glial stressors or activating signals contributes to neuropathic pain and... -
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- Axon Guidance Molecules Guiding Neuroinflammation
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Lee WS, Lee WH, Bae YC, Suk K
- KMID: 2451067
- Exp Neurobiol.
- 2019 Jun;28(3):311-319.
- doi: 10.5607/en.2019.28.3.311
Axon guidance molecules (AGMs), such as Netrins, Semaphorins, and Ephrins, have long been known to regulate axonal growth in the developing nervous system. Interestingly, the chemotactic properties of AGMs are... -
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- Pyruvate Dehydrogenase Kinase as a Potential Therapeutic Target for Malignant Gliomas
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Jha MK, Suk K
- KMID: 2048476
- Brain Tumor Res Treat.
- 2013 Oct;1(2):57-63.
- doi: 10.14791/btrt.2013.1.2.57
Metabolic aberrations in the form of altered flux through key metabolic pathways are the major hallmarks of several life-threatening malignancies including malignant gliomas. These adaptations play an important role in... -
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- Acute Phase Protein Lipocalin-2 Is Associated with Formalin-induced Nociception and Pathological Pain
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Jha MK, Jeon S, Jin M, Lee WH, Suk K
- KMID: 2150790
- Immune Netw.
- 2013 Dec;13(6):289-294.
- doi: 10.4110/in.2013.13.6.289
Lipocalin-2 (LCN2) is an acute-phase protein induced by injury, infection, or other inflammatory stimuli. LCN2 binds small hydrophobic ligands and interacts with cell surface receptor to regulate diverse cellular processes.... -
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- Spectral Modification by Operant Conditioning of Cortical Theta Suppression in Rats
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Roh M, Jang IS, Suk K, Lee MG
- KMID: 2441637
- Clin Psychopharmacol Neurosci.
- 2019 Feb;17(1):93-104.
- doi: 10.9758/cpn.2019.17.1.93
OBJECTIVE: Brain activity is known to be voluntarily controllable by neurofeedback, a kind of electroencephalographic (EEG) operant conditioning. Although its efficacy in clinical effects has been reported, it is yet... -
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- Lipocalin-2 Acts as a Neuroinflammatogen in Lipopolysaccharide-injected Mice
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Jin M, Jang E, Suk K
- KMID: 2165516
- Exp Neurobiol.
- 2014 Jun;23(2):155-162.
- doi: 10.5607/en.2014.23.2.155
Lipocalin-2 (LCN2) is a key mediator of various cellular processes. Recent studies have indicated that LCN2 also plays an important role in central nervous system (CNS) injuries and neurological diseases,... -
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- Delayed and Prolonged Local Brain Hypothermia Combined with Decompressive Craniectomy: A Novel Therapeutic Strategy That Modulates Glial Dynamics
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Kim JH, Yun SH, Jang KH, Park J, Han HS, Rhee D, Suk K
- KMID: 2165511
- Exp Neurobiol.
- 2014 Jun;23(2):115-123.
- doi: 10.5607/en.2014.23.2.115
Hypothermia is considered a useful intervention for limiting pathophysiological changes after brain injury. Local hypothermia is a relatively safe and convenient intervention that circumvents many of the complications associated with... -
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- Cell to Cell Interaction Can Activate Membrane-bound APRIL Which Are Expressed on Inflammatory Macrophages
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Lee SM, Kim WJ, Suk K, Lee WH
- KMID: 1456221
- Immune Netw.
- 2010 Oct;10(5):173-180.
- doi: 10.4110/in.2010.10.5.173
BACKGROUND: APRIL, originally known as a cytokine involved in B cell survival, is now known to regulate the inflammatory activation of macrophages. Although the signal initiated from APRIL has been... -
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- Comparative Analysis of Protein Tyrosine Phosphatases Regulating Microglial Activation
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Song GJ, Kim J, Kim JH, Song S, Park H, Zhang ZY, Suk K
- KMID: 2354878
- Exp Neurobiol.
- 2016 Oct;25(5):252-261.
- doi: 10.5607/en.2016.25.5.252
Protein tyrosine phosphatases (PTPs) are key regulatory factors in inflammatory signaling pathways. Although PTPs have been extensively studied, little is known about their role in neuroinflammation. In the present study,... -
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- The Stimulation of CD147 Induces MMP-9 Expression through ERK and NF-kappaB in Macrophages: Implication for Atherosclerosis
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Kim JY, Kim WJ, Kim H, Suk K, Lee WH
- KMID: 2150647
- Immune Netw.
- 2009 Jun;9(3):90-97.
- doi: 10.4110/in.2009.9.3.90
BACKGROUND: CD147, as a cellular receptor for cyclophilin A (CypA), is a multifunctional protein involved in tumor invasion, inflammation, tissue remodeling, neural function, and reproduction. Recent observations showing the expression... -
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- Involvement of Endoplasmic Reticulum Stress Response in Orofacial Inflammatory Pain
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Yang ES, Bae JY, Kim TH, Kim YS, Suk K, Bae YC
- KMID: 2165542
- Exp Neurobiol.
- 2014 Dec;23(4):372-380.
- doi: 10.5607/en.2014.23.4.372
Endoplasmic reticulum (ER) stress is involved in many neurological diseases and inflammatory responses. Inflammatory mediators induce neuronal damage and trigger the neuropathic or inflammatory pain. But there is very little... -
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- Apoptosis of Human Islet Cells by Cytokines
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Kim S, Kim KA, Suk K, Kim YH, Oh SH, Lee MK, Kim KW, Lee MS
- KMID: 2168009
- Immune Netw.
- 2012 Jun;12(3):113-117.
- doi: 10.4110/in.2012.12.3.113
FasL, perforin, TNFalpha, IL-1 and NO have been considered as effector molecule(s) leading to beta-cell death in autoimmune diabetes. However, the real culprit(s) of beta-cell destruction have long been elusive... -
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- Caffeine Maintains Arousal Level and Prevents Change of Electroencephalogram Spectral Powers with Time at Rest
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Jung JY, Lee HW, Jang IS, Suk K, Lee MG
- KMID: 2334723
- J Korean Sleep Res Soc.
- 2014 Jun;11(1):5-10.
OBJECTIVES: Although many studies have used quantitative electroencephalography (qEEG) analysis, some inconsistencies remain regarding the effects of caffeine. Among variables producing inconsistencies, the effect of selecting analyzing segment on caffeine... -
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- Modulation of Glial and Neuronal Migration by Lipocalin-2 in Zebrafish
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Kim H, Lee S, Park HC, Lee WH, Lee MS, Suk K
- KMID: 2150718
- Immune Netw.
- 2011 Dec;11(6):342-347.
- doi: 10.4110/in.2011.11.6.342
BACKGROUND: Glial cells are involved in immune and inflammatory responses in the central nervous system (CNS). Glial cells such as microglia and astrocytes also provide structural and functional support for... -
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- Deficiency of Lipocalin-2 Promotes Proliferation and Differentiation of Osteoclast Precursors via Regulation of c-Fms Expression and Nuclear Factor-kappa B Activation
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Kim HJ, Ohk B, Kang WY, Seong SJ, Suk K, Lim MS, Kim SY, Yoon YR
- KMID: 2156281
- J Bone Metab.
- 2016 Feb;23(1):8-15.
- doi: 10.11005/jbm.2016.23.1.8
BACKGROUND: Lipocalin-2 (LCN2), a small glycoprotein, has a pivotal role in diverse biological processes such as cellular proliferation and differentiation. We previously reported that LCN2 is implicated in osteoclast formation... -
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- Dieckol Attenuates Microglia-mediated Neuronal Cell Death via ERK, Akt and NADPH Oxidase-mediated Pathways
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Cui Y, Park JY, Wu J, Lee JH, Yang YS, Kang MS, Jung SC, Park JM, Yoo ES, Kim SH, Ahn Jo S, Suk K, Eun SY
- KMID: 1791422
- Korean J Physiol Pharmacol.
- 2015 May;19(3):219-228.
- doi: 10.4196/kjpp.2015.19.3.219
Excessive microglial activation and subsequent neuroinflammation lead to synaptic loss and dysfunction as well as neuronal cell death, which are involved in the pathogenesis and progression of several neurodegenerative diseases.... -
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